NEW: We are looking for volunteers to suggest or curate articles in particular research areas (mouse, xenobiotic resistance, etc.). Please contact us if you are interested.
Check our new BioRxiv paper on Vertebrate pigmentation: Elkin, J., Martin, A., Courtier-Orgogozo, V., & Santos, M. E. (2022). Meta-analysis of the genetic loci of pigment pattern evolution in vertebrates. bioRxiv.
Here is a list of previous findings based on Gephebase:
Courtier-Orgogozo V, Martin A (2020) The Coding Loci of Evolution and Domestication: Current Knowledge and Implications for Bio-Inspired Genome Editing. Journal of Experimental Biology 223: jeb208934. doi: 10.1242/jeb.208934
Courtier-Orgogozo V, Martin A, Arnoult L, Prigent S, Wiltgen S (2020) Gephebase, a Database of Genotype-Phenotype Relationships for natural and domesticated variation in Eukaryotes. Nucleic Acid Research 48(D1), D696-D703. doi:10.1093/nar/gkz796
Martin, A., & Courtier-Orgogozo, V. (2017). Morphological evolution repeatedly caused by mutations in signaling ligand genes. In Diversity and Evolution of Butterfly Wing Patterns (pp. 59-87). Springer, Singapore. Cis-regulatory tinkering of signaling ligand genes is a recurring mode of morphological evolution.
Arnoult, L. A. (2014). La marche génétique de l’évolution. Biologie Aujourd'hui, 208(3), 237-249. Current data are biased towards a limited number of model organisms.
Martin, A., & Orgogozo, V. (2013). The loci of repeated evolution: a catalog of genetic hotspots of phenotypic variation. Evolution, 67(5), 1235-1250. Independent evolution of similar traits in distant lineages often involves mutations in the same orthologous gene.
Streisfeld, M. A., & Rausher, M. D. (2011). Population genetics, pleiotropy, and the preferential fixation of mutations during adaptive evolution. Evolution: International Journal of Organic Evolution, 65(3), 629-642. Certain types of mutations are more likely to be fixed than others during the course of evolution.
Stern, D. L., & Orgogozo, V. (2009). Is genetic evolution predictable?. Science, 323(5915), 746-751. The mutations responsible for long-term evolution have distinct properties than the mutations responsible for short-term evolution.
Stern, D. L., & Orgogozo, V. (2008). The loci of evolution: how predictable is genetic evolution?. Evolution: International Journal of Organic Evolution, 62(9), 2155-2177. Studies have identified more coding mutations than cis-regulatory mutations underlying natural phenotypic variation. The mutations responsible for long-term evolution have distinct properties than the mutations responsible for short-term evolution.
7-10 April 2019: Virginie Courtier presented Gephebase at the Biocuration meeting in Cambridge.
September 2016: Conference on Gephebase and the loci of evolution, Paris.