Gephebase compiles genotype-phenotype relationships, i.e. associations between a mutation and a phenotypic variation. Gephebase consolidates data from the scientific literature about the genes and the mutations responsible for phenotypic variation in Eukaryotes (mostly animals, yeasts and plants). We plan to include non Eukaryote species in the future. For now, genes responsible for human disease and for aberrant mutant phenotypes in laboratory model organisms are excluded and can be found in other databases (OMIM, OMIA, FlyBase, etc.). QTL mapping studies that did not identify single genes are not included in Gephebase.

If you use Gephebase for your publication, please cite: Martin, A., & Orgogozo, V. (2013). The loci of repeated evolution: a catalog of genetic hotspots of phenotypic variation. Evolution, 67(5), 1235- 1250.

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LAST CURATED PAPERS

Kimchi-Sarfaty C ; Oh JM ; Kim IW et al. 2007.
A "silent" polymorphism in the MDR1 gene changes substrate specificity.

McPherron AC ; Lee SJ 1997.
Double muscling in cattle due to mutations in the myostatin gene.

Linder RA ; Greco JP ; Seidl F et al. 2017.
The Stress-Inducible Peroxidase TSA2 Underlies a Conditionally Beneficial Chromosomal Duplication in Saccharomyces cerevisiae.

WHAT'S NEW ?

Gephebase v.3.0 was launched on January 2019.

The new fields "Related Genes" and "Related Haplotypes" allow you to browse data related to your phenotype and taxon of interest.