Gephebase compiles genotype-phenotype relationships, i.e. associations between a mutation and a phenotypic variation. Gephebase consolidates data from the scientific literature about the genes and the mutations responsible for phenotypic variation in Eukaryotes (mostly animals, yeasts and plants). We plan to include non Eukaryote species in the future. For now, genes responsible for human disease and for aberrant mutant phenotypes in laboratory model organisms are excluded and can be found in other databases (OMIM, OMIA, FlyBase, etc.). QTL mapping studies that did not identify single genes are not included in Gephebase.

If you use Gephebase for your publication, please cite: Courtier-Orgogozo, V., Arnoult, L., Prigent, S. R., Wiltgen, S., & Martin, A. (2020). Gephebase, a database of genotype–phenotype relationships for natural and domesticated variation in Eukaryotes. Nucleic acids research, 48(D1), D696-D703.

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LAST CURATED PAPERS

Koch CT ; Bruggmann R ; Tetens J et al. 2013.
A non-coding genomic duplication at the HMX1 locus is associated with crop ears in highland cattle.

Lyons LA ; Creighton EK ; Alhaddad H et al. 2016.
Whole genome sequencing in cats, identifies new models for blindness in AIPL1 and somite segmentation in HES7.

Agarwal SK ; Cogburn LA ; Burnside J 1994.
Dysfunctional growth hormone receptor in a strain of sex-linked dwarf chicken: evidence for a mutation in the intracellular domain.

WHAT'S NEW ?

Gephebase v.3.0 was launched on January 2019.

The new fields "Related Genes" and "Related Haplotypes" allow you to browse data related to your phenotype and taxon of interest.