Gephebase compiles genotype-phenotype relationships, i.e. associations between a mutation and a phenotypic variation. Gephebase consolidates data from the scientific literature about the genes and the mutations responsible for phenotypic variation in Eukaryotes (mostly animals, yeasts and plants). We plan to include non Eukaryote species in the future. For now, genes responsible for human disease and for aberrant mutant phenotypes in laboratory model organisms are excluded and can be found in other databases (OMIM, OMIA, FlyBase, etc.). QTL mapping studies that did not identify single genes are not included in Gephebase.

If you use Gephebase for your publication, please cite: Courtier-Orgogozo, V., Arnoult, L., Prigent, S. R., Wiltgen, S., & Martin, A. (2020). Gephebase, a database of genotype–phenotype relationships for natural and domesticated variation in Eukaryotes. Nucleic acids research, 48(D1), D696-D703.

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LAST CURATED PAPERS

Arunkumar Ramesh ; Zhou Shuyu Olivia ; Day Jonathan P et al. 2022 .
Recurrent loss of an immunity gene that protects Drosophila against a major natural parasite

Wang HT ; Tsai CL ; Chen ME 2018.
Nicotinic acetylcholine receptor subunit α6 associated with spinosad resistance in Rhyzopertha dominica (Coleoptera: Bostrichidae).

Wang J ; Wang X ; Lansdell SJ et al. 2016.
A three amino acid deletion in the transmembrane domain of the nicotinic acetylcholine receptor α6 subunit confers high-level resistance to spinosad in Plutella xylostella.

WHAT'S NEW ?

A new review on the genetic loci of pigment pattern evolution in vertebrates, based on Gephebase, is now available in BioRxiv.

The new fields "Related Genes" and "Related Haplotypes" allow you to browse data related to your phenotype and taxon of interest.