Gephebase compiles genotype-phenotype relationships, i.e. associations between a mutation and a phenotypic variation. Gephebase consolidates data from the scientific literature about the genes and the mutations responsible for phenotypic variation in Eukaryotes (mostly animals, yeasts and plants). We plan to include non Eukaryote species in the future. For now, genes responsible for human disease and for aberrant mutant phenotypes in laboratory model organisms are excluded and can be found in other databases (OMIM, OMIA, FlyBase, etc.). QTL mapping studies that did not identify single genes are not included in Gephebase.
If you use Gephebase for your publication, please cite: Courtier-Orgogozo, V., Arnoult, L., Prigent, S. R., Wiltgen, S., & Martin, A. (2020). Gephebase, a database of genotype–phenotype relationships for natural and domesticated variation in Eukaryotes. Nucleic acids research, 48(D1), D696-D703.
LAST CURATED PAPERS
; Vieillard J
; Andrade P
A loss-of-function mutation in RORB disrupts saltatorial locomotion in rabbits.
Bruders R ; Van Hollebeke H ; Osborne EJ et al. 2020.
A copy number variant is associated with a spectrum of pigmentation patterns in the rock pigeon (Columba livia).
Derks MFL ; Lopes MS ; Bosse M et al. 2018.
Balancing selection on a recessive lethal deletion with pleiotropic effects on two neighboring genes in the porcine genome.
WHAT'S NEW ?
Gephebase v.3.0 was launched on January 2019.
The new fields "Related Genes" and "Related Haplotypes" allow you to browse data related to your phenotype and taxon of interest.