GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00002669
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Fundulus grandis - sensitive - lives in non-polluted sites
Trait State in Taxon B
Fundulus grandis - tolerant - adapted to polluted sites
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
Gulf killifish
Synonyms
Gulf killifish; Fundulus grandis Baird & Girard, 1853
Rank
species
Lineage
Show more ... leosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Fundulidae; Fundulus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
Gulf killifish
Synonyms
Gulf killifish; Fundulus grandis Baird & Girard, 1853
Rank
species
Lineage
Show more ... leosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Fundulidae; Fundulus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Ahr
Synonyms
Ah; In; Ahh; Ahre; bHLHe76
Sequence Similarities
-
GO - Biological Process
GO:0045944 : positive regulation of transcription by RNA polymerase II ... show more
UniProtKB
Mus musculus
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
Deletion Size
10-100 kb
Molecular Details of the Mutation
70 kb deletion that removes parts of the two genes AHR1a and AHR2a
Experimental Evidence
Authors
Oziolor EM; Reid NM; Yair S; Lee KM; Guberman VerPloeg S; Bruns PC; Shaw JR; Whitehead A; et al. ... show more
Abstract
Radical environmental change that provokes population decline can impose constraints on the sources of genetic variation that may enable evolutionary rescue. Adaptive toxicant resistance has rapidly evolved in Gulf killifish (Fundulus grandis) that occupy polluted habitats. We show that resistance scales with pollution level and negatively correlates with inducibility of aryl hydrocarbon receptor (AHR) signaling. Loci with the strongest signatures of recent selection harbor genes regulating AHR signaling. Two of these loci introgressed recently (18 to 34 generations ago) from Atlantic killifish (F. heteroclitus). One introgressed locus contains a deletion in AHR that confers a large adaptive advantage [selection coefficient (s) = 0.8]. Given the limited migration of killifish, recent adaptive introgression was likely mediated by human-assisted transport. We suggest that interspecies connectivity may be an important source of adaptive variation during extreme environmental change.

Copyright © 2019, American Association for the Advancement of Science.
Additional References
RELATED GEPHE
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@Introgression from Fundulus heteroclitus. Knockdown of AHR2a is protective of toxicity - @Fitness
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