ATP2B4
Pathogen resistance
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Timmann C; Thye T; Vens M ; et al. (2012)
Genome-wide association study indicates two novel resistance loci for severe malaria.
CCL3L1
Pathogen resistance
Gene Amplification,
Indel
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
Gonzalez E; Kulkarni H; Bolivar H ; et al. (2005)
The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility.
Duffy
Pathogen resistance
Cis-regulatory,
SNP
Homo sapiens
human - (species)
Intraspecific
Candidate Gene
Tournamille C; Colin Y; Cartron JP ; et al. (1995)
Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-n[...]
Glucose-6-phosphate dehydrogenase (G6PD)
Pathogen resistance
3 Mutations:
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Candidate Gene
2 References
Glycophorin GYPA-GYPB-GYPE cluster
Pathogen resistance
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
; Band G; Rockett KA ; et al. (2015)
A novel locus of resistance to severe malaria in a region of ancient balancing selection.
hemoglobin; HBB
Pathogen resistance
Coding,
SNP
Homo sapiens
human - (species) D
Intraspecific
Association Mapping
Jallow M; Teo YY; Small KS ; et al. (2009)
Genome-wide and fine-resolution association analysis of malaria in West Africa.
HLA-DRB1
Pathogen resistance
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Dunstan SJ; Hue NT; Han B ; et al. (2014)
Variation at HLA-DRB1 is associated with resistance to enteric fever.
Human Leukocyte Antigen-B (HLA-B)
Pathogen resistance
5 Mutations:
Coding,
SNP
Homo sapiens
human - (species)
Intraspecific
Association Mapping
; Pereyra F; Jia X ; et al. (2010)
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
MARVELD3
Pathogen resistance
Unknown,
Unknown
Homo sapiens
human - (species)
Intraspecific
Association Mapping
Timmann C; Thye T; Vens M ; et al. (2012)
Genome-wide association study indicates two novel resistance loci for severe malaria.
Mitochondrial antiviral signaling (MAVS)
Pathogen resistance
Coding,
SNP
Papio anubis
olive baboon - (species) D
Interspecific
Candidate Gene
Patel MR; Loo YM; Horner SM ; et al. (2012)
Convergent evolution of escape from hepaciviral antagonism in primates.
Mitochondrial antiviral signaling (MAVS)
Pathogen resistance
Coding,
SNP
Macaca mulatta
Rhesus monkey - (species) D
Interspecific
Candidate Gene
Patel MR; Loo YM; Horner SM ; et al. (2012)
Convergent evolution of escape from hepaciviral antagonism in primates.
Mitochondrial antiviral signaling (MAVS)
Pathogen resistance
Coding,
SNP
Ateles geoffroyi
black-handed spider monkey - (species) D
Interspecific
Candidate Gene
Patel MR; Loo YM; Horner SM ; et al. (2012)
Convergent evolution of escape from hepaciviral antagonism in primates.
Mitochondrial antiviral signaling (MAVS)
Pathogen resistance
Coding,
SNP
Plecturocebus moloch
red-bellied titi - (species) D
Interspecific
Candidate Gene
Patel MR; Loo YM; Horner SM ; et al. (2012)
Convergent evolution of escape from hepaciviral antagonism in primates.
Mitochondrial antiviral signaling (MAVS)
Pathogen resistance
Coding,
SNP
Allenopithecus nigroviridis
Allen's swamp monkey - (species) D
Interspecific
Candidate Gene
Patel MR; Loo YM; Horner SM ; et al. (2012)
Convergent evolution of escape from hepaciviral antagonism in primates.
SIGLEC13
Pathogen resistance
Gene Loss,
Complex Change
N
Homo sapiens
human - (species)
Interspecific
Candidate Gene
Wang X; Mitra N; Secundino I ; et al. (2012)
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.
SIGLEC17P (pseudogene)
Pathogen resistance
Coding,
Deletion
N
Homo sapiens
human - (species) D
Interspecific
Candidate Gene
Wang X; Mitra N; Secundino I ; et al. (2012)
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution.
TRIM5alpha
Pathogen resistance
Coding,
SNP
Cercopithecidae
Old World monkeys - (family)
Intraspecific
Candidate Gene
Newman RM; Hall L; Connole M ; et al. (2006)
Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha.
TRIM5alpha-CypA chimeric gene
Pathogen resistance
Other,
Insertion
Macaca
macaques - (genus)
Intergeneric or Higher
Candidate Gene
Stoye JP; Yap MW (2008)
Chance favors a prepared genome.
TRIM5alpha-CypA chimeric gene
Pathogen resistance
Other,
Insertion
Aotus
night monkeys - (genus)
Intergeneric or Higher
Candidate Gene
Sayah DM; Sokolskaja E; Berthoux L ; et al. (2004)
Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1.
1 Additional References