GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00000104
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait
Trait State in Taxon A
Saccharomyces cerevisiae - Bo213
Trait State in Taxon B
Saccharomyces cerevisiae - VL1
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Latin Name
Common Name
baker's yeast
Synonyms
Saccharomyces capensis; Saccharomyces italicus; Saccharomyces oviformis; Saccharomyces uvarum var. melibiosus; baker's yeast; S. cerevisiae; brewer's yeast; ATCC 18824; ATCC:18824; CBS 1171; CBS:1171; NRRL Y-12632; NRRL:Y:12632; Saccaromyces cerevisiae; Saccharomyce cerevisiae; Saccharomyes cerevisiae; Sccharomyces cerevisiae
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Fungi; Dikarya; Ascomycota; saccharomyceta; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Saccharomyces cerevisiae - Bo213
Taxon B
Latin Name
Common Name
baker's yeast
Synonyms
Saccharomyces capensis; Saccharomyces italicus; Saccharomyces oviformis; Saccharomyces uvarum var. melibiosus; baker's yeast; S. cerevisiae; brewer's yeast; ATCC 18824; ATCC:18824; CBS 1171; CBS:1171; NRRL Y-12632; NRRL:Y:12632; Saccaromyces cerevisiae; Saccharomyce cerevisiae; Saccharomyes cerevisiae; Sccharomyces cerevisiae
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Fungi; Dikarya; Ascomycota; saccharomyceta; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Saccharomyces cerevisiae - VL1
GENOTYPIC CHANGE
Generic Gene Name
APS1
Synonyms
YAP19; YLR170C; L9470.16
String
Sequence Similarities
Belongs to the adaptor complexes small subunit family.
GO - Molecular Function
GO - Biological Process
GO:0006896 : Golgi to vacuole transport
... show more
GO - Cellular Component
GO:0005634 : nucleus
... show more
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Asp142His
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | - | - | - |
Main Reference
Authors
Marullo P; Aigle M; Bely M; Masneuf-Pomarède I; Durrens P; Dubourdieu D; Yvert G
Abstract
Natural Saccharomyces cerevisiae yeast strains exhibit very large genotypic and phenotypic diversity. However, the link between phenotype variation and genetic determinism is still difficult to identify, especially in wild populations. Using genome hybridization on DNA microarrays, it is now possible to identify single-feature polymorphisms among divergent yeast strains. This tool offers the possibility of applying quantitative genetics to wild yeast strains. In this instance, we studied the genetic basis for variations in acetic acid production using progeny derived from two strains from grape must isolates. The trait was quantified during alcoholic fermentation of the two strains and 108 segregants derived from their crossing. A genetic map of 2212 markers was generated using oligonucleotide microarrays, and a major quantitative trait locus (QTL) was mapped with high significance. Further investigations showed that this QTL was due to a nonsynonymous single-nucleotide polymorphism that targeted the catalytic core of asparaginase type I (ASP1) and abolished its activity. This QTL was only effective when asparagine was used as a major nitrogen source. Our results link nitrogen assimilation and CO(2) production rate to acetic acid production, as well as, on a broader scale, illustrating the specific problem of quantitative genetics when working with nonlaboratory microorganisms.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
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