GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001063
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Panthera tigris
Trait State in Taxon B
Panthera tigris tigris - Bengal tiger (White tiger)
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
tiger
Synonyms
tiger
Rank
species
Lineage
Show more ... ata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
tiger
Synonyms
tiger
Rank
species
Lineage
Show more ... ata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Panthera tigris tigris - Bengal tiger (White tiger)
GENOTYPIC CHANGE
Generic Gene Name
SLC45A2
Synonyms
1A1; AIM1; MATP; OCA4; SHEP5
Sequence Similarities
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
A477V
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Xu X; Dong GX; Hu XS; Miao L; Zhang XL; Zhang DL; Yang HD; Zhang TY; et al. ... show more
Abstract
The white tiger, an elusive Bengal tiger (Panthera tigris tigris) variant with white fur and dark stripes, has fascinated humans for centuries ever since its discovery in the jungles of India. Many white tigers in captivity are inbred in order to maintain this autosomal recessive trait and consequently suffer some health problems, leading to the controversial speculation that the white tiger mutation is perhaps a genetic defect. However, the genetic basis of this phenotype remains unknown. Here, we conducted genome-wide association mapping with restriction-site-associated DNA sequencing (RAD-seq) in a pedigree of 16 captive tigers segregating at the putative white locus, followed by whole-genome sequencing (WGS) of the three parents. Validation in 130 unrelated tigers identified the causative mutation to be an amino acid change (A477V) in the transporter protein SLC45A2. Three-dimensional homology modeling suggests that the substitution may partially block the transporter channel cavity and thus affect melanogenesis. We demonstrate the feasibility of combining RAD-seq and WGS to rapidly map exotic variants in nonmodel organisms. Our results identify the basis of the longstanding white tiger mystery as the same gene underlying color variation in human, horse, and chicken and highlight its significance as part of the species' natural polymorphism that is viable in the wild.

Copyright © 2013 Elsevier Ltd. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
COMMENTS
YOUR FEEDBACK is welcome!