GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001066
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Drosophila mauritiana; and other Drosophila simulans strains
Trait State in Taxon B
Drosophila simulans - strain sim5 (7.8Hz lower sine song frequency than D. mauritiana)
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
-
Synonyms
-
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
-
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Drosophila simulans - strain sim5 (7.8Hz lower sine song frequency than D. mauritiana)
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
Insertion Size
1-10 kb
Molecular Details of the Mutation
6.7kb "Shelder" retroelement insertion in slowpoke intron; with effect on splicing
Experimental Evidence
Authors
Ding Y; Berrocal A; Morita T; Longden KD; Stern DL
Abstract
Animal species display enormous variation for innate behaviours, but little is known about how this diversity arose. Here, using an unbiased genetic approach, we map a courtship song difference between wild isolates of Drosophila simulans and Drosophila mauritiana to a 966 base pair region within the slowpoke (slo) locus, which encodes a calcium-activated potassium channel. Using the reciprocal hemizygosity test, we confirm that slo is the causal locus and resolve the causal mutation to the evolutionarily recent insertion of a retroelement in a slo intron within D. simulans. Targeted deletion of this retroelement reverts the song phenotype and alters slo splicing. Like many ion channel genes, slo is expressed widely in the nervous system and influences a variety of behaviours; slo-null males sing little song with severely disrupted features. By contrast, the natural variant of slo alters a specific component of courtship song, illustrating that regulatory evolution of a highly pleiotropic ion channel gene can cause modular changes in behaviour.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
COMMENTS
@Splicing The sim5 strain insertion is rare and derived within D. simulans - http://flybase.org/reports/FBal0343839
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