GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00001074
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
C._briggsae - AF16
Trait State in Taxon B
C._briggsae DR1690
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Caenorhabditis briggsae Dougherty & Nigon, 1949
Rank
species
Lineage
Show more ... s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
C._briggsae - AF16
Taxon B
Common Name
-
Synonyms
Caenorhabditis briggsae Dougherty & Nigon, 1949
Rank
species
Lineage
Show more ... s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
C._briggsae DR1690
GENOTYPIC CHANGE
Generic Gene Name
srg-34
Synonyms
CELE_Y51A2D.12; Y51A2D.12
Sequence Similarities
Belongs to the nematode receptor-like protein srg family.
UniProtKB
Caenorhabditis elegans
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
Deletion Size
1-10 kb
Molecular Details of the Mutation
33kb deletion
Experimental Evidence
Authors
McGrath PT; Xu Y; Ailion M; Garrison JL; Butcher RA; Bargmann CI
Abstract
Evolution can follow predictable genetic trajectories, indicating that discrete environmental shifts can select for reproducible genetic changes. Conspecific individuals are an important feature of an animal's environment, and a potential source of selective pressures. Here we show that adaptation of two Caenorhabditis species to growth at high density, a feature common to domestic environments, occurs by reproducible genetic changes to pheromone receptor genes. Chemical communication through pheromones that accumulate during high-density growth causes young nematode larvae to enter the long-lived but non-reproductive dauer stage. Two strains of Caenorhabditis elegans grown at high density have independently acquired multigenic resistance to pheromone-induced dauer formation. In each strain, resistance to the pheromone ascaroside C3 results from a deletion that disrupts the adjacent chemoreceptor genes serpentine receptor class g (srg)-36 and -37. Through misexpression experiments, we show that these genes encode redundant G-protein-coupled receptors for ascaroside C3. Multigenic resistance to dauer formation has also arisen in high-density cultures of a different nematode species, Caenorhabditis briggsae, resulting in part from deletion of an srg gene paralogous to srg-36 and srg-37. These results demonstrate rapid remodelling of the chemoreceptor repertoire as an adaptation to specific environments, and indicate that parallel changes to a common genetic substrate can affect life-history traits across species.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
COMMENTS
Cluster of paralogous genes
YOUR FEEDBACK is welcome!