GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001129
Main curator
Martin
PHENOTYPIC CHANGE
Trait #1
Trait Category
Trait
Trait State in Taxon A
Drosophila melanogaster - allele s-tim
Trait State in Taxon B
Drosophila melanogaster - allele ls-tim
Trait #2
Trait Category
Trait State in Taxon A
Drosophila melanogaster - allele s-tim
Trait State in Taxon B
Drosophila melanogaster - allele ls-tim - timls flies kept in constant light conditions show locomotor arrhythmicity as do wild-type flies. tims flies show a larger phase response to light pulses than timls flies.
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ... Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
TIMELESS
Synonyms
TIM; TIM1; hTIM; TIMELESS1
Sequence Similarities
Belongs to the timeless family.
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
Insertion Size
1-9 bp
Molecular Details of the Mutation
1bp insertion; allows production of longer protein from upstream start codon
Experimental Evidence
Authors
Tauber E; Zordan M; Sandrelli F; Pegoraro M; Osterwalder N; Breda C; Daga A; Selmin A; et al. ... show more
Abstract
Circadian and other natural clock-like endogenous rhythms may have evolved to anticipate regular temporal changes in the environment. We report that a mutation in the circadian clock gene timeless in Drosophila melanogaster has arisen and spread by natural selection relatively recently in Europe. We found that, when introduced into different genetic backgrounds, natural and artificial alleles of the timeless gene affect the incidence of diapause in response to changes in light and temperature. The natural mutant allele alters an important life history trait that may enhance the fly's adaptation to seasonal conditions.
RELATED GEPHE
Related Haplotypes
No matches found.
COMMENTS
http://flybase.org/reports/FBal0211083 - http://flybase.org/reports/FBal0211084
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