GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00001135
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Old World Monkeys
Trait State in Taxon B
Old World Monkeys
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Latin Name
Common Name
Old World monkeys
Synonyms
Old World monkeys; monkey; monkeys
Rank
family
Lineage
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mi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
Old World monkeys
Synonyms
Old World monkeys; monkey; monkeys
Rank
family
Lineage
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mi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
TRIM5
Synonyms
RNF88; TRIM5alpha
String
Sequence Similarities
Belongs to the TRIM/RBCC family.
GO - Molecular Function
GO:0042802 : identical protein binding
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GO - Biological Process
GO:0045087 : innate immune response
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GO - Cellular Component
GO:0005737 : cytoplasm
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Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
several a.a. substitutions with retrovirus-specific activities; under balancing selection in several species
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | - | - | - |
Main Reference
Authors
Newman RM; Hall L; Connole M; Chen GL; Sato S; Yuste E; Diehl W; Hunter E; et al.
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Abstract
Retroviral restriction factor TRIM5alpha exhibits a high degree of sequence variation among primate species. It has been proposed that this diversity is the cumulative result of ancient, lineage-specific episodes of positive selection. Here, we describe the contribution of within-species variation to the evolution of TRIM5alpha. Sampling within two geographically distinct Old World monkey species revealed extensive polymorphism, including individual polymorphisms that predate speciation (shared polymorphism). In some instances, alleles were more closely related to orthologues of other species than to one another. Both silent and nonsynonymous changes clustered in two domains. Functional assays revealed consequences of polymorphism, including differential restriction of a small panel of retroviruses by very similar alleles. Together, these features indicate that the primate TRIM5alpha locus has evolved under balancing selection. Except for the MHC there are few, if any, examples of long-term balancing selection in primates. Our results suggest a complex evolutionary scenario, in which fixation of lineage-specific adaptations is superimposed on a subset of critical polymorphisms that predate speciation events and have been maintained by balancing selection for millions of years.
Additional References
RELATED GEPHE
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@BalancingSelection
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