GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00001137
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Other Old World Monkeys (no HIV-1 restriction activity)
Trait State in Taxon B
Macaca spp. (HIV-1 restriction activity)
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Latin Name
Common Name
Old World monkeys
Synonyms
Old World monkeys; monkey; monkeys
Rank
family
Lineage
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mi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
macaques
Synonyms
macaques; macaque
Rank
genus
Lineage
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ipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Cercopithecinae
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
TRIM5
Synonyms
RNF88; TRIM5alpha
String
Sequence Similarities
Belongs to the TRIM/RBCC family.
GO - Molecular Function
GO:0042802 : identical protein binding
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GO - Biological Process
GO:0045087 : innate immune response
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GO - Cellular Component
GO:0005737 : cytoplasm
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Presumptive Null
Molecular Type
Aberration Type
Insertion Size
1-10 kb
Molecular Details of the Mutation
LINE-mediated retrotransposition of the CyclophilinA gene into 3'UTR (exon 8) of TRIM5alpha
Experimental Evidence
Main Reference
Authors
Stoye JP; Yap MW
Abstract
-
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@ChimericGene @TE; Trim5CypA2 clearly has restriction activity because it can block infection by HIV-2 simian immunodeficiency virus (SIV)AGMtan and feline immunodeficiency virus (FIV). This difference in restriction properties results from a point mutation leading to an H69R change in the CypA domain
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