GEPHE SUMMARY Print
Trait State in Taxon A
Trait State in Taxon B
Sus scrofa; wild boars; Bornean bearded pig (S.barbatus); wart hog (Phacochoerus africanus); and red river hog(Potamochoerus porcus).
Show more ... Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Show more ... Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Generic Gene Name
Ucp; Slc25a7; AI385626
Belongs to the mitochondrial carrier (TC 2.A.29) family.
GO - Molecular Function
GO:0005525 : GTP binding ... show more
GO - Biological Process
GO - Cellular Component
GO:0016021 : integral component of membrane ... show more
Molecular Details of the Mutation
deletion of exons 3 to 5
Berg F; Gustafson U; Andersson L
Piglets appear to lack brown adipose tissue, a specific type of fat that is essential for nonshivering thermogenesis in mammals, and they rely on shivering as the main mechanism for thermoregulation. Here we provide a genetic explanation for the poor thermoregulation in pigs as we demonstrate that the gene for uncoupling protein 1 (UCP1) was disrupted in the pig lineage. UCP1 is exclusively expressed in brown adipose tissue and plays a crucial role for thermogenesis by uncoupling oxidative phosphorylation. We used long-range PCR and genome walking to determine the complete genome sequence of pig UCP1. An alignment with human UCP1 revealed that exons 3 to 5 were eliminated by a deletion in the pig sequence. The presence of this deletion was confirmed in all tested domestic pigs, as well as in European wild boars, Bornean bearded pigs, wart hogs, and red river hogs. Three additional disrupting mutations were detected in the remaining exons. Furthermore, the rate of nonsynonymous substitutions was clearly elevated in the pig sequence compared with the corresponding sequences in humans, cattle, and mice, and we used this increased rate to estimate that UCP1 was disrupted about 20 million years ago.
Note that the derived phenotype may have appeared during evolution due to another mutation; and that the mutation described here might have occurred subsequently; as a neutral mutation.
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