GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001209
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Heliconius cydno alithea - polymorphic Ecuadorian population : presence of white hourglass pattern in discal cell
Trait State in Taxon B
Heliconius cydno alithea - polymorphic Ecuadorian population : absence of white hourglass pattern in discal cell
Ancestral State
Unknown
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Heliconius cydno Doubleday, 1847
Rank
species
Lineage
Show more ... dylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Papilionoidea; Nymphalidae; Heliconiinae; Heliconiini; Heliconius
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Heliconius cydno alithea - polymorphic Ecuadorian population : presence of white hourglass pattern in discal cell
Taxon B
Common Name
-
Synonyms
Heliconius cydno Doubleday, 1847
Rank
species
Lineage
Show more ... dylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Papilionoidea; Nymphalidae; Heliconiinae; Heliconiini; Heliconius
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Heliconius cydno alithea - polymorphic Ecuadorian population : absence of white hourglass pattern in discal cell
GENOTYPIC CHANGE
Generic Gene Name
WntA
Synonyms
-
String
-
Sequence Similarities
Belongs to the Wnt family.
UniProtKB
Vanessa cardui
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Indel Size
1-10 kb
Molecular Details of the Mutation
1.8-kb indel that was perfectly associated with variation in forewing melanin patterning
Experimental Evidence
Authors
Gallant JR; Imhoff VE; Martin A; Savage WK; Chamberlain NL; Pote BL; Peterson C; Smith GE; et al. ... show more
Abstract
Convergent evolution provides a rare, natural experiment with which to test the predictability of adaptation at the molecular level. Little is known about the molecular basis of convergence over macro-evolutionary timescales. Here we use a combination of positional cloning, population genomic resequencing, association mapping and developmental data to demonstrate that positionally orthologous nucleotide variants in the upstream region of the same gene, WntA, are responsible for parallel mimetic variation in two butterfly lineages that diverged >65 million years ago. Furthermore, characterization of spatial patterns of WntA expression during development suggests that alternative regulatory mechanisms underlie wing pattern variation in each system. Taken together, our results reveal a strikingly predictable molecular basis for phenotypic convergence over deep evolutionary time.
RELATED GEPHE
Related Genes
Related Haplotypes
1
COMMENTS
Transposon with cis-regulatory effect (Gene Expression Shift) ; Admixture Mapping in Polymorphic Population reinforcing previous Linkage Mapping result.
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