GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001219
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Xiphophorus maculatus
Trait State in Taxon B
Xiphophorus helleri
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
southern platyfish
Synonyms
Platypoecilus maculatus; southern platyfish; Platypoecilus maculatus Guenther, 1866; Xiphophorus maculatus (Guenther, 1866)
Rank
species
Lineage
Show more ... oteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Poeciliidae; Poeciliinae; Xiphophorus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
green swordtail
Synonyms
Xiphophorus helleri; green swordtail; Xiphophorus hellerii Heckel, 1848
Rank
species
Lineage
Show more ... oteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Poeciliidae; Poeciliinae; Xiphophorus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
xmrk
Synonyms
tu
String
-
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
UniProtKB
Xiphophorus maculatus
GenebankID or UniProtKB
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Various
Experimental Evidence
Authors
Adam D; Dimitrijevic N; Schartl M
Abstract
Melanoma formation in the teleost Xiphophorus is caused by a dominant genetic locus, Tu. This locus includes the Xmrk oncogene, which encodes a receptor tyrosine kinase. Tumor induction is suppressed in wild-type fish by a tumor suppressor locus, R. Molecular genetic analyses revealed that the Tu locus emerged by nonhomologous recombination of the Xmrk proto-oncogene with a previously uncharacterized sequence, D. This event generated an additional copy of Xmrk with a new promoter. Suppression of the new Xmrk promoter by R in parental fish and its deregulation in hybrids explain the genetics of melanoma formation in Xiphophorus.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
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