GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00001223
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait
Trait State in Taxon A
Drosophila spp.
Trait State in Taxon B
Drosophila biarmipes
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
-
Synonyms
Drosophila (Drosophila); Drosophila (Drosophila) Fallen, 1823
Rank
subgenus
Lineage
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icondylia; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
-
Synonyms
-
Rank
species
Lineage
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era; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; suzukii subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
y
Synonyms
CG3757; Dmel\CG3757; EG:125H10.2; T6; Y
String
Sequence Similarities
Belongs to the major royal jelly protein family.
GO - Molecular Function
-
GO - Biological Process
GO:0042438 : melanin biosynthetic process
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GO - Cellular Component
GO:0005737 : cytoplasm
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Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
wing spot repressor element; within a 675-bp fragment;
Experimental Evidence
Main Reference
Authors
Gompel N; Prud'homme B; Wittkopp PJ; Kassner VA; Carroll SB
Abstract
The gain, loss or modification of morphological traits is generally associated with changes in gene regulation during development. However, the molecular bases underlying these evolutionary changes have remained elusive. Here we identify one of the molecular mechanisms that contributes to the evolutionary gain of a male-specific wing pigmentation spot in Drosophila biarmipes, a species closely related to Drosophila melanogaster. We show that the evolution of this spot involved modifications of an ancestral cis-regulatory element of the yellow pigmentation gene. This element has gained multiple binding sites for transcription factors that are deeply conserved components of the regulatory landscape controlling wing development, including the selector protein Engrailed. The evolutionary stability of components of regulatory landscapes, which can be co-opted by chance mutations in cis-regulatory elements, might explain the repeated evolution of similar morphological patterns, such as wing pigmentation patterns in flies.
Additional References
RELATED GEPHE
Related Haplotypes
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