GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00000128
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Hyaloperonospora parasitica - pathogenic
Trait State in Taxon B
Hyaloperonospora parasitica - non pathogenic
Ancestral State
Data not curated
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Peronospora parasitica; Hyaloperonospora parasitica (Persoon: Fries) Constantinescu
Rank
species
Lineage
cellular organisms; Eukaryota; Stramenopiles; Oomycetes; Peronosporales; Peronosporaceae; Hyaloperonospora; Hyaloperonospora parasitica species group
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
Peronospora parasitica; Hyaloperonospora parasitica (Persoon: Fries) Constantinescu
Rank
species
Lineage
cellular organisms; Eukaryota; Stramenopiles; Oomycetes; Peronosporales; Peronosporaceae; Hyaloperonospora; Hyaloperonospora parasitica species group
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Atr13
Synonyms
-
String
-
Sequence Similarities
-
GO - Molecular Function
-
GO - Biological Process
-
GO - Cellular Component
-
UniProtKB
Hyaloperonospora parasitica
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Multiple coding changes - the avirulence allele ATR13‐Maks9 and the virulence allele ATR13‐Emoy2 only encode differences in the C‐terminal domain (in 11 amino acids) - domain swaps show that one or more of the amino acids in Region A are required for recognition and one or more in Region B are required to elicit a full recognition phenotype. - exact causing mutations unknown
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Allen RL; Bittner-Eddy PD; Grenville-Briggs LJ; Meitz JC; Rehmany AP; Rose LE; Beynon JL
Abstract
Plants are constantly exposed to attack by an array of diverse pathogens but lack a somatically adaptive immune system. In spite of this, natural plant populations do not often suffer destructive disease epidemics. Elucidating how allelic diversity within plant genes that function to detect pathogens (resistance genes) counteracts changing structures of pathogen genes required for host invasion (pathogenicity effectors) is critical to our understanding of the dynamics of natural plant populations. The RPP13 resistance gene is the most polymorphic gene analyzed to date in the model plant Arabidopsis thaliana. Here we report the cloning of the avirulence gene, ATR13, that triggers RPP13-mediated resistance, and we show that it too exhibits extreme levels of amino acid polymorphism. Evidence of diversifying selection visible in both components suggests that the host and pathogen may be locked in a coevolutionary conflict at these loci, where attempts to evade host resistance by the pathogen are matched by the development of new detection capabilities by the host.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@SeveralMutationsWithEffect
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