GEPHE SUMMARY Print
Entry Status
Published
GepheID
GP00001288
Main curator
Arnoult
PHENOTYPIC CHANGE
Trait #1
Trait Category
Trait State in Taxon A
Gasterosteus aculeatus (marine)
Trait State in Taxon B
Gasterosteus aculeatus (freshwater) - low TH
Trait #2
Trait Category
Trait State in Taxon A
-
Trait State in Taxon B
-
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
three-spined stickleback
Synonyms
three-spined stickleback; three spined stickleback; Gasterosteus aculeatus Linnaeus, 1758
Rank
species
Lineage
Show more ... a; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Gasterosteus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Gasterosteus aculeatus (marine)
Taxon B
Common Name
three-spined stickleback
Synonyms
three-spined stickleback; three spined stickleback; Gasterosteus aculeatus Linnaeus, 1758
Rank
species
Lineage
Show more ... a; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Gasterosteus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Gasterosteus aculeatus (freshwater) - low TH
GENOTYPIC CHANGE
Generic Gene Name
tshba
Synonyms
tshb
Sequence Similarities
Belongs to the glycoprotein hormones subunit beta family.
UniProtKB
Danio rerio
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
unknown
Experimental Evidence
Authors
Kitano J; Lema SC; Luckenbach JA; Mori S; Kawagishi Y; Kusakabe M; Swanson P; Peichel CL
Abstract
During adaptive radiations, animals colonize diverse environments, which requires adaptation in multiple phenotypic traits. Because hormones mediate the dynamic regulation of suites of phenotypic traits, evolutionary changes in hormonal signaling pathways might contribute to adaptation to new environments. Here we report changes in the thyroid hormone signaling pathway in stream-resident ecotypes of threespine stickleback fish (Gasterosteus aculeatus), which have repeatedly evolved from ancestral marine ecotypes. Stream-resident fish exhibit a lower plasma concentration of thyroid hormone and a lower metabolic rate, which is likely adaptive for permanent residency in small streams. The thyroid-stimulating hormone-β2 (TSHβ2) gene exhibited significantly lower mRNA expression in pituitary glands of stream-resident sticklebacks relative to marine sticklebacks. Some of the difference in TSHβ2 transcript levels can be explained by cis-regulatory differences at the TSHβ2 gene locus. Consistent with these expression differences, a strong signature of divergent natural selection was found at the TSHβ2 genomic locus. By contrast, there were no differences between the marine and stream-resident ecotypes in mRNA levels or genomic sequence in the paralogous TSHβ1 gene. Our data indicate that evolutionary changes in hormonal signaling have played an important role in the postglacial adaptive radiation of sticklebacks.

Copyright © 2010 Elsevier Ltd. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
COMMENTS
The marine ecotype has significantly higher levels of TSHb2 mRNA than the stream- resident ecotype
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