GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00001313
Main curator
Arnoult
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Saccharomyces cerevisiae S288c
Trait State in Taxon B
Saccharomyces paradoxus CBS432
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
baker's yeast
Synonyms
Saccharomyces capensis; Saccharomyces italicus; Saccharomyces oviformis; Saccharomyces uvarum var. melibiosus; baker's yeast; S. cerevisiae; brewer's yeast; ATCC 18824; ATCC:18824; CBS 1171; CBS:1171; NRRL Y-12632; NRRL:Y:12632; Saccaromyces cerevisiae; Saccharomyce cerevisiae; Saccharomyes cerevisiae; Sccharomyces cerevisiae
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Fungi; Dikarya; Ascomycota; saccharomyceta; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Saccharomyces cerevisiae S288c
Taxon B
Common Name
-
Synonyms
AS 2.2401; AS:2.2401; BCRC:22587; CBS 432; CBS:432; CCRC 22587; CCRC:22587; CLIB 228; CLIB:228; DBVPG 6411; DBVPG:6411; IFO 10609; IFO:10609; IGC 4570; IGC:4570; MUCL 31498; MUCL:31498; NCYC 2600; NCYC:2600; NRRL Y-17217; NRRL:Y:17217; PYCC 4570; PYCC:4570
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Fungi; Dikarya; Ascomycota; saccharomyceta; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Saccharomyces paradoxus CBS432
GENOTYPIC CHANGE
UniProtKB
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
mutations within 1kb in promotor region
Experimental Evidence
Authors
Naranjo S; Smith JD; Artieri CG; Zhang M; Zhou Y; Palmer ME; Fraser HB
Abstract
Although single genes underlying several evolutionary adaptations have been identified, the genetic basis of complex, polygenic adaptations has been far more challenging to pinpoint. Here we report that the budding yeast Saccharomyces paradoxus has recently evolved resistance to citrinin, a naturally occurring mycotoxin. Applying a genome-wide test for selection on cis-regulation, we identified five genes involved in the citrinin response that are constitutively up-regulated in S. paradoxus. Four of these genes are necessary for resistance, and are also sufficient to increase the resistance of a sensitive strain when over-expressed. Moreover, cis-regulatory divergence in the promoters of these genes contributes to resistance, while exacting a cost in the absence of citrinin. Our results demonstrate how the subtle effects of individual regulatory elements can be combined, via natural selection, into a complex adaptation. Our approach can be applied to dissect the genetic basis of polygenic adaptations in a wide range of species.
Additional References
RELATED GEPHE
COMMENTS
A total of 4 genes involved in resistance to citrinin found in this study
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