GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001320
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
C. elegans
Trait State in Taxon B
C. elegans - Hawaii strain CB4856 and 16 other strains
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
-
Synonyms
roundworm; Rhabditis elegans; Caenorhabditis elegans (Maupas, 1900); Rhabditis elegans Maupas, 1900
Rank
species
Lineage
Show more ... s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
roundworm; Rhabditis elegans; Caenorhabditis elegans (Maupas, 1900); Rhabditis elegans Maupas, 1900
Rank
species
Lineage
Show more ... s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
C. elegans - Hawaii strain CB4856 and 16 other strains
GENOTYPIC CHANGE
Generic Gene Name
peel-1
Synonyms
CELE_Y39G10AR.25; Y39G10AR.25
Sequence Similarities
-
GO - Molecular Function
-
GO - Biological Process
-
UniProtKB
Caenorhabditis elegans
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
Deletion Size
10-100 kb
Molecular Details of the Mutation
19kb deletion
Experimental Evidence
Authors
Seidel HS; Rockman MV; Kruglyak L
Abstract
Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel-1 arrest if their sperm parent carries an incompatible allele of a second, paternal-effect locus, peel-1. The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes. These haplotypes exhibit elevated sequence divergence, and population genetic analyses of this region indicate that natural selection is preserving both haplotypes in the population. Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome.
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
COMMENTS
@BalancingSelection - The 19-kb deletion removes 2 genes; zeel-1 and peel-1. Signature of balancing selection. The large haplotype region spans 33 kb of Bristol sequence and includes four full genes and part of a fifth. Sequencing of multiple strains suggests a single deletion event ; Null mutation
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