GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00001333
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Chestnut-bellied flycatcher-chesnut-bellied form of Makira island
Trait State in Taxon B
Chestnut-bellied flycatcher-melanic form of Santa Ana island
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
Makira monarch
Synonyms
Makira monarch; Monarcha castaneiventris Verreaux, J, 1858
Rank
species
Lineage
Show more ... tetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Monarchidae; Monarcha
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Chestnut-bellied flycatcher-chesnut-bellied form of Makira island
Taxon B
Common Name
Makira monarch
Synonyms
Makira monarch; Monarcha castaneiventris Verreaux, J, 1858
Rank
species
Lineage
Show more ... tetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea; Monarchidae; Monarcha
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Chestnut-bellied flycatcher-melanic form of Santa Ana island
GENOTYPIC CHANGE
Generic Gene Name
MC1R
Synonyms
CMM5; MSH-R; SHEP2; MSHR
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Asp119Asn
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Uy JA; Cooper EA; Cutie S; Concannon MR; Poelstra JW; Moyle RG; Filardi CE
Abstract
The independent evolution of similar traits across multiple taxa provides some of the most compelling evidence of natural selection. Little is known, however, about the genetic basis of these convergent or parallel traits: are they mediated by identical or different mutations in the same genes, or unique mutations in different genes? Using a combination of candidate gene and reduced representation genomic sequencing approaches, we explore the genetic basis of and the evolutionary processes that mediate similar plumage colour shared by isolated populations of the Monarcha castaneiventris flycatcher of the Solomon Islands. A genome-wide association study (GWAS) that explicitly controlled for population structure revealed that mutations in known pigmentation genes are the best predictors of parallel plumage colour. That is, entirely black or melanic birds from one small island share an amino acid substitution in the melanocortin-1 receptor (MC1R), whereas similarly melanic birds from another small island over 100 km away share an amino acid substitution in a predicted binding site of agouti signalling protein (ASIP). A third larger island, which separates the two melanic populations, is inhabited by birds with chestnut bellies that lack the melanic MC1R and ASIP allelic variants. Formal FST outlier tests corroborated the results of the GWAS and suggested that strong, directional selection drives the near fixation of the MC1R and ASIP variants across islands. Our results, therefore, suggest that selection acting on different mutations with large phenotypic effects can drive the evolution of parallel melanism, despite the relatively small population size on islands.

© 2016 The Author(s).
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
COMMENTS
2 other candidate regions were identified but without known gene
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