GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Reviewed
GepheID
GP00001339
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
European barn owl-White
Trait State in Taxon B
European barn owl-Rufous
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
Barn owl
Synonyms
Strix alba; Barn owl; Schleiereule; Tyto alba (Scopoli, 1769)
Rank
species
Lineage
Show more ... rcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
Barn owl
Synonyms
Strix alba; Barn owl; Schleiereule; Tyto alba (Scopoli, 1769)
Rank
species
Lineage
Show more ... rcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Strigiformes; Tytonidae; Tyto
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
MC1R
Synonyms
CMM5; MSH-R; SHEP2; MSHR
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
p.Val126Ile
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid Val Ile 126
Authors
San-Jose LM; Ducrest AL; Ducret V; Béziers P; Simon C; Wakamatsu K; Roulin A
Abstract
Variants of the melanocortin-1 receptor (MC1R) gene result in abrupt, naturally selected colour morphs. These genetic variants may differentially affect sexual dimorphism if one morph is naturally selected in the two sexes but another morph is naturally or sexually selected only in one of the two sexes (e.g. to confer camouflage in reproductive females or confer mating advantage in males). Therefore, the balance between natural and sexual selections can differ between MC1R variants, as suggest studies showing interspecific correlations between sexual dimorphism and the rate of nonsynonymous vs. synonymous amino acid substitutions at the MC1R. Surprisingly, how MC1R is related to within-species sexual dimorphism, and thereby to sex-specific selection, has not yet been investigated. We tackled this issue in the barn owl (Tyto alba), a species showing pronounced variation in the degree of reddish pheomelanin-based coloration and in the number and size of black feather spots. We found that a valine (V)-to-isoleucine (I) substitution at position 126 explains up to 30% of the variation in the three melanin-based colour traits and in feather melanin content. Interestingly, MC1R genotypes also differed in the degree of sexual colour dimorphism, with individuals homozygous for the II MC1R variant being 2 times redder and 2.5 times less sexually dimorphic than homozygous individuals for the VV MC1R variant. These findings support that MC1R interacts with the expression of sexual dimorphism and suggest that a gene with major phenotypic effects and weakly influenced by variation in body condition can participate in sex-specific selection processes.

© 2015 John Wiley & Sons Ltd.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
COMMENTS
rufous allele is dominant over white allele @SexualDimorphism @Pleiotropy
YOUR FEEDBACK is welcome!