GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001381
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Threespined stickleback fish ; marine habitat of Pacific basin
Trait State in Taxon B
Threespined stickleback fish ; freshwater habitat of Pacific basin
Ancestral State
Unknown
Taxonomic Status
Taxon A
Common Name
three-spined stickleback
Synonyms
three-spined stickleback; three spined stickleback; Gasterosteus aculeatus Linnaeus, 1758
Rank
species
Lineage
Show more ... a; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Gasterosteus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Threespined stickleback fish ; marine habitat of Pacific basin
Taxon B
Common Name
three-spined stickleback
Synonyms
three-spined stickleback; three spined stickleback; Gasterosteus aculeatus Linnaeus, 1758
Rank
species
Lineage
Show more ... a; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Gasterosteus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Threespined stickleback fish ; freshwater habitat of Pacific basin
GENOTYPIC CHANGE
Generic Gene Name
PRKCD
Synonyms
MAY1; PKCD; ALPS3; CVID9; nPKC-delta
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
GO - Biological Process
GO:0007165 : signal transduction ... show more
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
unknown
Experimental Evidence
Authors
Jones FC; Chan YF; Schmutz J; Grimwood J; Brady SD; Southwick AM; Absher DM; Myers RM; et al. ... show more
Abstract
Genes underlying repeated adaptive evolution in natural populations are still largely unknown. Stickleback fish (Gasterosteus aculeatus) have undergone a recent dramatic evolutionary radiation, generating numerous examples of marine-freshwater species pairs and a small number of benthic-limnetic species pairs found within single lakes [1]. We have developed a new genome-wide SNP genotyping array to study patterns of genetic variation in sticklebacks over a wide geographic range, and to scan the genome for regions that contribute to repeated evolution of marine-freshwater or benthic-limnetic species pairs. Surveying 34 global populations with 1,159 informative markers revealed substantial genetic variation, with predominant patterns reflecting demographic history and geographic structure. After correcting for geographic structure and filtering for neutral markers, we detected large repeated shifts in allele frequency at some loci, identifying both known and novel loci likely contributing to marine-freshwater and benthic-limnetic divergence. Several novel loci fall close to genes implicated in epithelial barrier or immune functions, which have likely changed as sticklebacks adapt to contrasting environments. Specific alleles differentiating sympatric benthic-limnetic species pairs are shared in nearby solitary populations, suggesting an allopatric origin for adaptive variants and selection pressures unrelated to sympatry in the initial formation of these classic vertebrate species pairs.

Copyright © 2012 Elsevier Ltd. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
Candidate locus ; mapping is not precise enough
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