GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001386
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
WT Bombyx mori strain (N4; P50) and non-domesticated Bombyx mandarina
Trait State in Taxon B
Bombyx mori strain c05 with pS larval color phenotype or strain p50T with +p phenotype
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
domestic silkworm
Synonyms
domestic silkworm; silk moth; silkworm; Bombyx mori Linnaeus, 1758
Rank
species
Lineage
Show more ... xapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Bombycoidea; Bombycidae; Bombycinae; Bombyx
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
WT Bombyx mori strain (N4; P50) and non-domesticated Bombyx mandarina
Taxon B
Latin Name
Common Name
domestic silkworm
Synonyms
domestic silkworm; silk moth; silkworm; Bombyx mori Linnaeus, 1758
Rank
species
Lineage
Show more ... xapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Bombycoidea; Bombycidae; Bombycinae; Bombyx
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Bombyx mori strain c05 with pS larval color phenotype or strain p50T with +p phenotype
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
233-kb region around apt-like (pS) refined as 33kb interval in apt-like Intron 1 (+p) with uncharacterized haplotype driving apt-like upregulation in derived phenotypes
Experimental Evidence
Authors
Yoda S; Yamaguchi J; Mita K; Yamamoto K; Banno Y; Ando T; Daimon T; Fujiwara H
Abstract
Genetic polymorphisms underlie the convergent and divergent evolution of various phenotypes. Diverse colour patterns on caterpillars, which are ecologically important, are good models for understanding the molecular backgrounds of phenotypic diversity. Here we show that a single evolutionarily conserved gene apontic-like (apt-like) encoding for a putative transcription factor accounts for the silkworm p locus, which causes at least 15 different larval markings involved in branch-like markings and eye-spot formation. The expression of apt-like and melanin synthesis genes are upregulated in association with pigmented areas of marking mutants Striped (p(S)) and normal (+(p)) but not in the non-marking allele plain (p). Functional analyses, ectopic expression, RNAi and TALEN, demonstrate that apt-like causes melanin pigmentation in a cell-autonomous manner. These results suggest that variation in p alleles is caused by the differential expression of the gene apt-like which induces targeted elevation of gene expressions in the melanin synthesis pathway.
EXTERNAL LINKS
COMMENTS
Allelic differences between +p and pS were uncharacterized and are included here as a single allelic variant rather than as an allelic series ; TALEN loss-of-function and electroporation experiments validate the role of apt-like in pigment pattern formation
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