GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001400
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Drosophila serrata female light form
Trait State in Taxon B
Drosophila serrata female dark form
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Drosophila serrata Malloch, 1927
Rank
species
Lineage
Show more ... eura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; montium subgroup; Drosophila serrata species complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
Drosophila serrata Malloch, 1927
Rank
species
Lineage
Show more ... eura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; montium subgroup; Drosophila serrata species complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
pdm3
Synonyms
BcDNA:AT16994; CG11641; CG14755; CG42698; Dmel\CG42698; Pdm3; Dmel_CG42698
String
-
Sequence Similarities
Belongs to the POU transcription factor family.
GO - Cellular Component
UniProtKB
Drosophila melanogaster
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
1st intron variant divergent in length and sequence. Dark haplotype contains four tandem sets of three motifs.
Experimental Evidence
Authors
Yassin A; Delaney EK; Reddiex AJ; Seher TD; Bastide H; Appleton NC; Lack JB; David JR; et al. ... show more
Abstract
Sex-limited polymorphisms are an intriguing form of sexual dimorphism that offer unique opportunities to reconstruct the evolutionary changes that decouple male and female traits encoded by a shared genome. We investigated the genetic basis of a Mendelian female-limited color dimorphism (FLCD) that segregates in natural populations of more than 20 species of the Drosophila montium subgroup. In these species, females have alternative abdominal color morphs, light and dark, whereas males have only one color morph in each species. A comprehensive molecular phylogeny of the montium subgroup supports multiple origins of FLCD. Despite this, we mapped FLCD to the same locus in four distantly related species-the transcription factor POU domain motif 3 (pdm3), which acts as a repressor of abdominal pigmentation in D. melanogaster. In D. serrata, FLCD maps to a structural variant in the first intron of pdm3; however, this variant is not found in the three other species-D. kikkawai, D. leontia, and D. burlai-and sequence analysis strongly suggests the pdm3 alleles responsible for FLCD originated independently at least three times. We propose that cis-regulatory changes in pdm3 form sexually dimorphic and monomorphic alleles that segregate within species and are preserved, at least in one species, by structural variation. Surprisingly, pdm3 has not been implicated in the evolution of sex-specific pigmentation outside the montium subgroup, suggesting that the genetic paths to sexual dimorphism may be constrained within a clade but variable across clades.

Copyright © 2016 Elsevier Ltd. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
COMMENTS
@SexualTrait - dominant dark allele. Dark allele may have formed via tandem duplications of a flanking precursor motif
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