GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00001414
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
ancestral colobine monkey with RNASE1B similar to RNASE1A
Trait State in Taxon B
asian colobine monkey (P. melalophos) with adapted RNASE1B to low pH
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
-
Synonyms
-
Rank
subfamily
Lineage
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Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
mitred leaf monkey
Synonyms
mitred leaf monkey; Presbytis melalophos (Raffles 1821)
Rank
species
Lineage
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etrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Colobinae; Presbytis
Parent
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
RNASE1B
Synonyms
-
String
-
Sequence Similarities
Belongs to the pancreatic ribonuclease family.
GO - Molecular Function
GO:0003676 : nucleic acid binding
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GO - Biological Process
-
GO - Cellular Component
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
p.Arg39Gln
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | - | - | - |
Main Reference
Authors
Zhou X; Wang B; Pan Q; Zhang J; Kumar S; Sun X; Liu Z; Pan H; et al.
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Abstract
Colobines are a unique group of Old World monkeys that principally eat leaves and seeds rather than fruits and insects. We report the sequencing at 146× coverage, de novo assembly and analyses of the genome of a male golden snub-nosed monkey (Rhinopithecus roxellana) and resequencing at 30× coverage of three related species (Rhinopithecus bieti, Rhinopithecus brelichi and Rhinopithecus strykeri). Comparative analyses showed that Asian colobines have an enhanced ability to derive energy from fatty acids and to degrade xenobiotics. We found evidence for functional evolution in the colobine RNASE1 gene, encoding a key secretory RNase that digests the high concentrations of bacterial RNA derived from symbiotic microflora. Demographic reconstructions indicated that the profile of ancient effective population sizes for R. roxellana more closely resembles that of giant panda rather than its congeners. These findings offer new insights into the dietary adaptations and evolutionary history of colobine primates.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
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