GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001416
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
-
Trait State in Taxon B
-
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
polar bear
Synonyms
Thalarctos maritimus; polar bear; white bear
Rank
species
Lineage
Show more ... rata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
giant panda
Synonyms
giant panda; Ailuropoda melanoleuca (David, 1869); Ailuropoda melanoleura
Rank
species
Lineage
Show more ... Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Tas1r1
Synonyms
TR1; T1r1; Gpr70; Tr1
Sequence Similarities
Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily.
UniProtKB
Mus musculus
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
Deletion Size
-
Molecular Details of the Mutation
pseudogene due to three indel mutations in the third and sixth exons. The giant panda has one 2-bp insertion on the third exon and two deletions (6-bp and 4-bp) on the sixth exon,
Experimental Evidence
Authors
Li R; Fan W; Tian G; Zhu H; He L; Cai J; Huang Q; Cai Q; et al. ... show more
Abstract
Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The assembled contigs (2.25 gigabases (Gb)) cover approximately 94% of the whole genome, and the remaining gaps (0.05 Gb) seem to contain carnivore-specific repeats and tandem repeats. Comparisons with the dog and human showed that the panda genome has a lower divergence rate. The assessment of panda genes potentially underlying some of its unique traits indicated that its bamboo diet might be more dependent on its gut microbiome than its own genetic composition. We also identified more than 2.7 million heterozygous single nucleotide polymorphisms in the diploid genome. Our data and analyses provide a foundation for promoting mammalian genetic research, and demonstrate the feasibility for using next-generation sequencing technologies for accurate, cost-effective and rapid de novo assembly of large eukaryotic genomes.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
1
EXTERNAL LINKS
COMMENTS
Note that the derived phenotype may have appeared during evolution due to another mutation; and that the mutation described here might have occurred subsequently; as a neutral mutation.
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