GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001423
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Labeotropheus trewavasae & Metriaclima zebra large blotched morph
Trait State in Taxon B
Labeotropheus trewavasae & Metriaclima zebra light blotched morph
Ancestral State
Unknown
Taxonomic Status
Taxon A
Common Name
-
Synonyms
scrapermouth mbuna; Labeotropheus trewavasae Fryer, 1956; Labeotropheus trewavassae
Rank
species
Lineage
Show more ... ypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini; Labeotropheus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
scrapermouth mbuna; Labeotropheus trewavasae Fryer, 1956; Labeotropheus trewavassae
Rank
species
Lineage
Show more ... ypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini; Labeotropheus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Pax7
Synonyms
Pax-7
Sequence Similarities
Belongs to the paired homeobox family.
UniProtKB
Mus musculus
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
unknown
Experimental Evidence
Authors
Roberts RB; Moore EC; Kocher TD
Abstract
Despite long-standing interest in the evolution and maintenance of discrete phenotypic polymorphisms, the molecular genetic basis of such polymorphism in the wild is largely unknown. Female sex-associated blotched colour polymorphisms found in cichlids of Lake Malawi, East Africa, represent a highly successful polymorphic phenotype, found and maintained in four genera across the geographic expanse of the lake. Previously, we identified an association with an allelic variant of the paired-box transcription factor gene pax7a and blotched colour morphs in Lake Malawi cichlid fishes. Although a diverse range of blotched phenotypes are present in Lake Malawi cichlid species, they all appeared to result from an allele of pax7a that produces increased levels of transcript. Here, we examine the developmental and genetic basis of variation among blotched morphs. First, we confirm that pax7a-associated blotch morphs result primarily from modulation of melanophore development and survival. From laboratory crosses and natural population studies, we identify at least three alleles of pax7a associated with discrete subtypes of blotched morphs, in addition to the ancestral pax7a allele. Genotypes at pax7a support initial evolution of a novel pax7a allele to produce the blotched class of morphs, followed by subsequent evolution of that pax7a blotched allele to produce additional alleles associated with discrete colour morphs. Variant alleles of pax7a produce different levels of pax7a transcript, correlating with pigmentation phenotype at the cellular level. This naturally selected allelic series should serve as a case study for understanding the molecular genetic control of pax7a expression and the evolution of sex-associated alleles.

© 2016 John Wiley & Sons Ltd.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
2
COMMENTS
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