GEPHE SUMMARY Print
Entry Status
Published
GepheID
GP00001457
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Common pink flower from population in south central Oregon portion of the Modoc Plateau
Trait State in Taxon B
Rare white flower from population near Crater Lake in the Oregon Cascades
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Mimulus lewisii; Erythranthe lewisii (Pursh) G.L.Nesom & N.S.Fraga; Mimulus lewisii Pursh
Rank
species
Lineage
Show more ... Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Phrymaceae; Erythranthe
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Common pink flower from population in south central Oregon portion of the Modoc Plateau
Taxon B
Common Name
-
Synonyms
Mimulus lewisii; Erythranthe lewisii (Pursh) G.L.Nesom & N.S.Fraga; Mimulus lewisii Pursh
Rank
species
Lineage
Show more ... Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Phrymaceae; Erythranthe
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Rare white flower from population near Crater Lake in the Oregon Cascades
GENOTYPIC CHANGE
Generic Gene Name
DFRA
Synonyms
dihydroflavonol 4-reductase; DIHYDROFLAVONOL 4-REDUCTASE; DIHYDROKAEMPFEROL 4-REDUCTASE; M318; MJB21.18; MJB21_18; TT3; DFR; At5g42800
Sequence Similarities
Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.
UniProtKB
Arabidopsis thaliana
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
Insertion Size
1-9 bp
Molecular Details of the Mutation
A 2 nt (TG) insertion at position 265 causing a frameshift and a greatly truncated protein of 106 aa only about one-fourth of its functional length
Experimental Evidence
Authors
Wu CA; Streisfeld MA; Nutter LI; Cross KA
Abstract
A long-standing question in evolutionary biology asks whether the genetic changes contributing to phenotypic evolution are predictable. Here, we identify a genetic change associated with segregating variation in flower color within a population of Mimulus lewisii. To determine whether these types of changes are predictable, we combined this information with data from other species to investigate whether the spectrum of mutations affecting flower color transitions differs based on the evolutionary time-scale since divergence. We used classic genetic techniques, along with gene expression and population genetic approaches, to identify the putative, loss-of-function mutation that generates rare, white flowers instead of the common, pink color in M. lewisii. We found that a frameshift mutation in an anthocyanin pathway gene is responsible for the white-flowered polymorphism found in this population of M. lewisii. Comparison of our results with data from other species reveals a broader spectrum of flower color mutations segregating within populations relative to those that fix between populations. These results suggest that the genetic basis of fixed differences in flower color may be predictable, but that for segregating variation is not.
Additional References
RELATED GEPHE
Related Haplotypes
No matches found.
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