GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00001463
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Anopheles gambiae susceptible to Plasmodium falciparum infection
Trait State in Taxon B
Anopheles gambiae resistant to Plasmodium falciparum infection
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
African malaria mosquito
Synonyms
Anopheles gambiae S; African malaria mosquito; Anopheles gambiae Giles, 1902; Anopheles gambia
Rank
species
Lineage
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tacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Pyretophorus; gambiae species complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
African malaria mosquito
Synonyms
Anopheles gambiae S; African malaria mosquito; Anopheles gambiae Giles, 1902; Anopheles gambia
Rank
species
Lineage
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tacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Pyretophorus; gambiae species complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
ADA
Synonyms
ADA1
String
Sequence Similarities
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
GO - Molecular Function
GO:0008270 : zinc ion binding
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GO - Biological Process
GO:0007155 : cell adhesion
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GO - Cellular Component
GO:0005886 : plasma membrane
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Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
c.C427T p.R143C
Experimental Evidence
Taxon A | Taxon B | Position | |
---|---|---|---|
Codon | - | - | - |
Amino-acid | - | - | - |
Main Reference
Authors
Li J; Wang X; Zhang G; Githure JI; Yan G; James AA
Abstract
The malaria parasite-resistance island (PRI) of the African mosquito vector, Anopheles gambiae, was mapped to five genomic regions containing 80 genes, using coexpression patterns of genomic blocks. High-throughput sequencing identified 347 nonsynonymous single-nucleotide polymorphisms within these genes in mosquitoes from malaria-endemic areas in Kenya. Direct association studies between nonsynonymous single-nucleotide polymorphisms and Plasmodium falciparum infection identified three naturally occurring genetic variations in each of three genes (An. gambiae adenosine deaminase, fibrinogen-related protein 30, and fibrinogen-related protein 1) that were associated significantly with parasite infection. A role for these genes in the resistance phenotype was confirmed by RNA interference knockdown assays. Silencing fibrinogen-related protein 30 increased parasite infection significantly, whereas ablation of fibrinogen-related protein 1 transcripts resulted in mosquitoes nearly free of parasites. The discovered genes and single-nucleotide polymorphisms are anticipated to be useful in the development of tools for malaria control in endemic areas in Africa.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
the role of the gene is confirmed by RNA interference knockdown assays. Silencing of the gene slightly reduced parasite infection by P. berghei
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