GEPHE SUMMARY Print
Entry Status
Published
GepheID
GP00001464
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Anopheles gambiae susceptible to Plasmodium falciparum infection
Trait State in Taxon B
Anopheles gambiae resistant to Plasmodium falciparum infection
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
African malaria mosquito
Synonyms
Anopheles gambiae S; African malaria mosquito; Anopheles gambiae Giles, 1902; Anopheles gambia
Rank
species
Lineage
Show more ... tacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Pyretophorus; gambiae species complex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
African malaria mosquito
Synonyms
Anopheles gambiae S; African malaria mosquito; Anopheles gambiae Giles, 1902; Anopheles gambia
Rank
species
Lineage
Show more ... tacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicomorpha; Culicoidea; Culicidae; Anophelinae; Anopheles; Cellia; Pyretophorus; gambiae species complex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
1270165
Synonyms
AgaP_AGAP006914
Sequence Similarities
-
GO - Molecular Function
-
GO - Biological Process
-
GO - Cellular Component
-
UniProtKB
Anopheles gambiae
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
c.T28C p.F10L
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Li J; Wang X; Zhang G; Githure JI; Yan G; James AA
Abstract
The malaria parasite-resistance island (PRI) of the African mosquito vector, Anopheles gambiae, was mapped to five genomic regions containing 80 genes, using coexpression patterns of genomic blocks. High-throughput sequencing identified 347 nonsynonymous single-nucleotide polymorphisms within these genes in mosquitoes from malaria-endemic areas in Kenya. Direct association studies between nonsynonymous single-nucleotide polymorphisms and Plasmodium falciparum infection identified three naturally occurring genetic variations in each of three genes (An. gambiae adenosine deaminase, fibrinogen-related protein 30, and fibrinogen-related protein 1) that were associated significantly with parasite infection. A role for these genes in the resistance phenotype was confirmed by RNA interference knockdown assays. Silencing fibrinogen-related protein 30 increased parasite infection significantly, whereas ablation of fibrinogen-related protein 1 transcripts resulted in mosquitoes nearly free of parasites. The discovered genes and single-nucleotide polymorphisms are anticipated to be useful in the development of tools for malaria control in endemic areas in Africa.
Additional References
EXTERNAL LINKS
COMMENTS
the role of the gene is confirmed by RNA interference knockdown assays. Silencing of the gene increased parasite infection by P. berghei
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