GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001489
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Budding yeast Y55 laboratory strain from wine (France)
Trait State in Taxon B
Budding yeast evolved clone in 1% glucose 48h condition with decreased growth rate during fermentation (R ferm ) and increased time to diauxic shift (T shift )
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
baker's yeast
Synonyms
Saccharomyces capensis; Saccharomyces italicus; Saccharomyces oviformis; Saccharomyces uvarum var. melibiosus; baker's yeast; S. cerevisiae; brewer's yeast; ATCC 18824; ATCC:18824; CBS 1171; CBS:1171; NRRL Y-12632; NRRL:Y:12632; Saccaromyces cerevisiae; Saccharomyce cerevisiae; Saccharomyes cerevisiae; Sccharomyces cerevisiae
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Fungi; Dikarya; Ascomycota; saccharomyceta; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Budding yeast Y55 laboratory strain from wine (France)
Taxon B
Common Name
baker's yeast
Synonyms
Saccharomyces capensis; Saccharomyces italicus; Saccharomyces oviformis; Saccharomyces uvarum var. melibiosus; baker's yeast; S. cerevisiae; brewer's yeast; ATCC 18824; ATCC:18824; CBS 1171; CBS:1171; NRRL Y-12632; NRRL:Y:12632; Saccaromyces cerevisiae; Saccharomyce cerevisiae; Saccharomyes cerevisiae; Sccharomyces cerevisiae
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Fungi; Dikarya; Ascomycota; saccharomyceta; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Budding yeast evolved clone in 1% glucose 48h condition with decreased growth rate during fermentation (R ferm ) and increased time to diauxic shift (T shift )
GENOTYPIC CHANGE
Presumptive Null
Yes
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsense
Molecular Details of the Mutation
G>T p.E214*. Truncated protein will lack the final helix of the C-terminus as well as a glutamine repeat known to be involved in protein/protein interactions
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Spor A; Kvitek DJ; Nidelet T; Martin J; Legrand J; Dillmann C; Bourgais A; de Vienne D; et al. ... show more
Abstract
Different organisms have independently and recurrently evolved similar phenotypic traits at different points throughout history. This phenotypic convergence may be caused by genotypic convergence and in addition, constrained by historical contingency. To investigate how convergence may be driven by selection in a particular environment and constrained by history, we analyzed nine life-history traits and four metabolic traits during an experimental evolution of six yeast strains in four different environments. In each of the environments, the population converged toward a different multivariate phenotype. However, the evolution of most traits, including fitness components, was constrained by history. Phenotypic convergence was partly associated with the selection of mutations in genes involved in the same pathway. By further investigating the convergence in one gene, BMH1, mutated in 20% of the evolved populations, we show that both the history and the environment influenced the types of mutations (missense/nonsense), their location within the gene itself, as well as their effects on multiple traits. However, these effects could not be easily predicted from ancestors' phylogeny or past selection. Combined, our data highlight the role of pleiotropy and epistasis in shaping a rugged fitness landscape.

© 2013 The Author(s). Evolution © 2013 The Society for the Study of Evolution.
Additional References
COMMENTS
Bmh1p functions in nutrient signaling and mitotic cell cycle. Bmh1 has an impact on the reproduction rate in fermentation and respiration the length of fermentation (until the diauxic shift) and on cell size. Which traits controlled by Bmh1p have been selected for in this experiment remains to be studied. Mutations are observed in other genes that may also be causative.
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