GEPHE SUMMARY Print
GepheID
GP00001508
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Snub-nosed monkey of lowland regions (R. brelichi)
Trait State in Taxon B
Snub-nosed monkey of high-altitude habitats (R. roxellana)
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
Gray snub-nosed monkey
Synonyms
Pygathrix brelichi; Gray snub-nosed monkey
Rank
species
Lineage
Show more ... podomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Colobinae; Rhinopithecus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
golden snub-nosed monkey
Synonyms
Pygathrix roxellana; golden snub-nosed monkey; Rhinopithecus roxellana (Milne-Edwards, 1870); Rhinopithecus roxellanae
Rank
species
Lineage
Show more ... podomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Cercopithecoidea; Cercopithecidae; Colobinae; Rhinopithecus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
CDT1
Synonyms
DUP; RIS2
Sequence Similarities
Belongs to the Cdt1 family.
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
p.Ala537Val
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Yu L; Wang GD; Ruan J; Chen YB; Yang CP; Cao X; Wu H; Liu YH; et al. ... show more
Abstract
The snub-nosed monkey genus Rhinopithecus includes five closely related species distributed across altitudinal gradients from 800 to 4,500 m. Rhinopithecus bieti, Rhinopithecus roxellana, and Rhinopithecus strykeri inhabit high-altitude habitats, whereas Rhinopithecus brelichi and Rhinopithecus avunculus inhabit lowland regions. We report the de novo whole-genome sequence of R. bieti and genomic sequences for the four other species. Eight shared substitutions were found in six genes related to lung function, DNA repair, and angiogenesis in the high-altitude snub-nosed monkeys. Functional assays showed that the high-altitude variant of CDT1 (Ala537Val) renders cells more resistant to UV irradiation, and the high-altitude variants of RNASE4 (Asn89Lys and Thr128Ile) confer enhanced ability to induce endothelial tube formation in vitro. Genomic scans in the R. bieti and R. roxellana populations identified signatures of selection between and within populations at genes involved in functions relevant to high-altitude adaptation. These results provide valuable insights into the adaptation to high altitude in the snub-nosed monkeys.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@Introgression. Common substitution observed in high-altitude snub-nosed monkeys. identified as evolving under positive selection along the lineage containing R. bieti and R. strykeri and the lineage leading to R. roxellana. Experimental validation: UV irradiation assays showed that CDT1 Ala537Val was more stable than the reference CDT1 protein after irradiation with 100 J/m 2 UV light. CDT1 is a licensing factor for DNA replication that is tightly controlled to maintain genome integrity and the encoded protein is rapidly degraded by the SCF Skp2 complex upon UV-induced DNA damage
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