GEPHE SUMMARY Print
Entry Status
Published
GepheID
GP00000162
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Pectinophora gossypiella - Bt susceptible
Trait State in Taxon B
Pectinophora gossypiella - Bt resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
pink bollworm
Synonyms
pink bollworm; Pectinophora gossypiella (Saunders, 1844); Pectinophora gassypiella
Rank
species
Lineage
Show more ... Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Gelechioidea; Gelechiidae; Pexicopiinae; Pectinophora
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
pink bollworm
Synonyms
pink bollworm; Pectinophora gossypiella (Saunders, 1844); Pectinophora gassypiella
Rank
species
Lineage
Show more ... Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Gelechioidea; Gelechiidae; Pexicopiinae; Pectinophora
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Presumptive Null
Yes
Molecular Type
Aberration Type
Deletion Size
100-999 bp
Molecular Details of the Mutation
126bp in-frame deletion
Experimental Evidence
Authors
Morin S; Biggs RW; Sisterson MS; Shriver L; Ellers-Kirk C; Higginson D; Holley D; Gahan LJ; et al. ... show more
Abstract
Evolution of resistance by pests is the main threat to long-term insect control by transgenic crops that produce Bacillus thuringiensis (Bt) toxins. Because inheritance of resistance to the Bt toxins in transgenic crops is typically recessive, DNA-based screening for resistance alleles in heterozygotes is potentially much more efficient than detection of resistant homozygotes with bioassays. Such screening, however, requires knowledge of the resistance alleles in field populations of pests that are associated with survival on Bt crops. Here we report that field populations of pink bollworm (Pectinophora gossypiella), a major cotton pest, harbored three mutant alleles of a cadherin-encoding gene linked with resistance to Bt toxin Cry1Ac and survival on transgenic Bt cotton. Each of the three resistance alleles has a deletion expected to eliminate at least eight amino acids upstream of the putative toxin-binding region of the cadherin protein. Larvae with two resistance alleles in any combination were resistant, whereas those with one or none were susceptible to Cry1Ac. Together with previous evidence, the results reported here identify the cadherin gene as a leading target for DNA-based screening of resistance to Bt crops in lepidopteran pests.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
3
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