GEPHE SUMMARY Print
Entry Status
Published
GepheID
GP00000165
Main curator
Martin
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Pectinophora gossypiella - Bt susceptible
Trait State in Taxon B
Pectinophora gossypiella - Bt resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
pink bollworm
Synonyms
pink bollworm; Pectinophora gossypiella (Saunders, 1844); Pectinophora gassypiella
Rank
species
Lineage
Show more ... Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Gelechioidea; Gelechiidae; Pexicopiinae; Pectinophora
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
pink bollworm
Synonyms
pink bollworm; Pectinophora gossypiella (Saunders, 1844); Pectinophora gassypiella
Rank
species
Lineage
Show more ... Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Holometabola; Amphiesmenoptera; Lepidoptera; Glossata; Neolepidoptera; Heteroneura; Ditrysia; Gelechioidea; Gelechiidae; Pexicopiinae; Pectinophora
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
E1266L R1268E and E1270V - whether each mutation has an effect or only one of them is unknown
Experimental Evidence
Taxon A Taxon B Position
Codon - - -
Amino-acid - - -
Authors
Zhang H; Tian W; Zhao J; Jin L; Yang J; Liu C; Yang Y; Wu S; et al. ... show more
Abstract
Evolution of pest resistance reduces the efficacy of insecticidal proteins from Bacillus thuringiensis (Bt) used in sprays or in transgenic crops. Although several pests have evolved resistance to Bt crops in the field, information about the genetic basis of field-evolved resistance to Bt crops has been limited. In particular, laboratory-selected resistance to Bt toxin Cry1Ac based on recessive mutations in a gene encoding a toxin-binding cadherin protein has been identified in three major cotton pests, but previous work has not determined if such mutations are associated with field-selected resistance to Bt cotton. Here we show that the most common resistance alleles in field populations of cotton bollworm, Helicoverpa armigera, selected with Bt cotton in northern China, had recessive cadherin mutations, including the deletion mutation identified via laboratory selection. However, unlike all previously studied cadherin resistance alleles, one field-selected cadherin resistance allele conferred nonrecessive resistance. We also detected nonrecessive resistance that was not genetically linked with the cadherin locus. In field-selected populations, recessive cadherin alleles accounted for 75-84% of resistance alleles detected. However, most resistance alleles occurred in heterozygotes and 59-94% of resistant individuals carried at least one nonrecessive resistance allele. The results suggest that resistance management strategies must account for diverse resistance alleles in field-selected populations, including nonrecessive alleles.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
3
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