GEPHE SUMMARY Print
Entry Status
Published
GepheID
GP00001677
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait
Trait State in Taxon A
Species with captive median lifespan of 12 months
Trait State in Taxon B
Species with short lifespan of 7.5 months
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
bluefin notho
Synonyms
bluefin notho; Nothobranchius rachovii Ahl, 1926
Rank
species
Lineage
Show more ... pha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Aplocheiloidei; Nothobranchiidae; Nothobranchius
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
N. rachovii with captive median lifespan of 12 months
Taxon B
Common Name
-
Synonyms
Nothobranchius pienaari Shidlovskiy, Watters & Wildekamp, 2010
Rank
species
Lineage
Show more ... pha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Aplocheiloidei; Nothobranchiidae; Nothobranchius
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
N. pienaari with short lifespan of 7.5 months
GENOTYPIC CHANGE
Generic Gene Name
ID3
Synonyms
HEIR-1; bHLHb25; 1R21; BHLHB25; HEIR1
Sequence Similarities
-
UniProtKB
Homo sapiens
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Deletion Size
1-9 bp
Molecular Details of the Mutation
One evolutionarily conserved aa (E) is deleted in id3 C-terminus
Experimental Evidence
Authors
Reichwald K; Petzold A; Koch P; Downie BR; Hartmann N; Pietsch S; Baumgart M; Chalopin D; et al. ... show more
Abstract
The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic development (diapause) make it an attractive model organism in biomedical research. Here, we report a draft sequence of its genome that allowed us to uncover an intra-species Y chromosome polymorphism representing-in real time-different stages of sex chromosome formation that display features of early mammalian XY evolution "in action." Our data suggest that gdf6Y, encoding a TGF-β family growth factor, is the master sex-determining gene in N. furzeri. Moreover, we observed genomic clustering of aging-related genes, identified genes under positive selection, and revealed significant similarities of gene expression profiles between diapause and aging, particularly for genes controlling cell cycle and translation. The annotated genome sequence is provided as an online resource (http://www.nothobranchius.info/NFINgb).

Copyright © 2015 Elsevier Inc. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
Link with phenotype unclear
YOUR FEEDBACK is welcome!