GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00001678
Main curator
Prigent
PHENOTYPIC CHANGE
Trait Category
Trait
Trait State in Taxon A
Strain with a maximum lifespan of ~1 year
Trait State in Taxon B
Strain from Zimbabwe with a maximum lifespan of 4-6 months
Ancestral State
Unknown
Taxonomic Status
Taxon A
Latin Name
Common Name
turquoise killifish
Synonyms
turquoise killifish; Nothobranchius furzeri Jubb, 1971
Rank
species
Lineage
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pha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Aplocheiloidei; Nothobranchiidae; Nothobranchius
NCBI Taxonomy ID
is Taxon A an Infraspecies?
Yes
Taxon A Description
Killifish MZM-0410
Taxon B
Latin Name
Common Name
turquoise killifish
Synonyms
turquoise killifish; Nothobranchius furzeri Jubb, 1971
Rank
species
Lineage
Show more ...
pha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Aplocheiloidei; Nothobranchiidae; Nothobranchius
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
Killifish GRZ strain from Zimbabwe
GENOTYPIC CHANGE
Generic Gene Name
IKBIP
Synonyms
IKIP
String
-
Sequence Similarities
-
GO - Molecular Function
-
GO - Biological Process
GO - Cellular Component
GO:0016021 : integral component of membrane
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UniProtKB
Homo sapiens
Homo sapiens
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
Under positive selection; down regulated in aging skin
Experimental Evidence
Main Reference
Authors
Reichwald K; Petzold A; Koch P; Downie BR; Hartmann N; Pietsch S; Baumgart M; Chalopin D; et al.
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Abstract
The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic development (diapause) make it an attractive model organism in biomedical research. Here, we report a draft sequence of its genome that allowed us to uncover an intra-species Y chromosome polymorphism representing-in real time-different stages of sex chromosome formation that display features of early mammalian XY evolution "in action." Our data suggest that gdf6Y, encoding a TGF-β family growth factor, is the master sex-determining gene in N. furzeri. Moreover, we observed genomic clustering of aging-related genes, identified genes under positive selection, and revealed significant similarities of gene expression profiles between diapause and aging, particularly for genes controlling cell cycle and translation. The annotated genome sequence is provided as an online resource (http://www.nothobranchius.info/NFINgb).
Copyright © 2015 Elsevier Inc. All rights reserved.
Copyright © 2015 Elsevier Inc. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
Related Haplotypes
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