GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00001680
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Two hypandrial bristles
Trait State in Taxon B
No hypandrial bristles ; Additional sex comb teeth
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
-
Synonyms
Drosophila yakuba Burla, 1954
Rank
species
Lineage
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Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
-
Synonyms
-
Rank
species
Lineage
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Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
sc
Synonyms
AS-C T4; AS-C T4sc; ascT4; bHLHc28; CG3827; Dmel\CG3827; DROACS2; EG:198A6.1; Hw; l(1)1Ba; Sc; sc/T4; scalpha; scute/sisterlessB; SC_DA; sis b; sis-b; sisb; sisB; T4; T4 AS-C
String
Sequence Similarities
-
GO - Molecular Function
GO - Biological Process
GO:0007419 : ventral cord development
... show more
GO - Cellular Component
UniProtKB
Drosophila melanogaster
Drosophila melanogaster
GenebankID or UniProtKB
Mutation #1
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
T1775G - decreases scute expression in the developing genitalia and thus reduces the number of hypandrial bristles. Also increases scute expression in the developing leg and thus increases the number of sex comb teeth. The mutation alters a binding site for Abd-B.
Experimental Evidence
Main Reference
Authors
Nagy O; Nuez I; Savisaar R; Peluffo AE; Yassin A; Lang M; Stern DL; Matute DR; et al.
... show more
Abstract
Diverse traits often covary between species [1-3]. The possibility that a single mutation could contribute to the evolution of several characters between species [3] is rarely investigated as relatively few cases are dissected at the nucleotide level. Drosophila santomea has evolved additional sex comb sensory teeth on its legs and has lost two sensory bristles on its genitalia. We present evidence that a single nucleotide substitution in an enhancer of the scute gene contributes to both changes. The mutation alters a binding site for the Hox protein Abdominal-B in the developing genitalia, leading to bristle loss, and for another factor in the developing leg, leading to bristle gain. Our study suggests that morphological evolution between species can occur through a single nucleotide change affecting several sexually dimorphic traits. VIDEO ABSTRACT.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Additional References
Mutation #2
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
T1429G - decreases scute expression in the developing genitalia and thus reduces the number of hypandrial bristles. No effect on sex comb tooth number.
Experimental Evidence
Main Reference
Authors
Nagy O; Nuez I; Savisaar R; Peluffo AE; Yassin A; Lang M; Stern DL; Matute DR; et al.
... show more
Abstract
Diverse traits often covary between species [1-3]. The possibility that a single mutation could contribute to the evolution of several characters between species [3] is rarely investigated as relatively few cases are dissected at the nucleotide level. Drosophila santomea has evolved additional sex comb sensory teeth on its legs and has lost two sensory bristles on its genitalia. We present evidence that a single nucleotide substitution in an enhancer of the scute gene contributes to both changes. The mutation alters a binding site for the Hox protein Abdominal-B in the developing genitalia, leading to bristle loss, and for another factor in the developing leg, leading to bristle gain. Our study suggests that morphological evolution between species can occur through a single nucleotide change affecting several sexually dimorphic traits. VIDEO ABSTRACT.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Additional References
Mutation #3
Presumptive Null
Molecular Type
Aberration Type
Molecular Details of the Mutation
A1407G - decreases scute expression in the developing genitalia and thus reduces the number of hypandrial bristles. No effect on sex comb tooth number.
Experimental Evidence
Main Reference
Authors
Nagy O; Nuez I; Savisaar R; Peluffo AE; Yassin A; Lang M; Stern DL; Matute DR; et al.
... show more
Abstract
Diverse traits often covary between species [1-3]. The possibility that a single mutation could contribute to the evolution of several characters between species [3] is rarely investigated as relatively few cases are dissected at the nucleotide level. Drosophila santomea has evolved additional sex comb sensory teeth on its legs and has lost two sensory bristles on its genitalia. We present evidence that a single nucleotide substitution in an enhancer of the scute gene contributes to both changes. The mutation alters a binding site for the Hox protein Abdominal-B in the developing genitalia, leading to bristle loss, and for another factor in the developing leg, leading to bristle gain. Our study suggests that morphological evolution between species can occur through a single nucleotide change affecting several sexually dimorphic traits. VIDEO ABSTRACT.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@SexualTrait - Several genes contribute to the trait change and several cis-regulatory mutations within scute contribute to the reduction in scute expression
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