GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001684
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Solanum lycopersicum domesticated - low total- and alpha-tocopherol content
Trait State in Taxon B
Solanum lycopersicum domesticated - high total- and alpha-tocopherol content
Ancestral State
Unknown
Taxonomic Status
Taxon A
Common Name
tomato
Synonyms
Lycopersicon esculentum var. esculentum; Solanum esculentum; Solanum lycopersicum var. humboldtii; tomato; Lycopersicon esculentum Mill.; Solanum esculentum Dunal; Solanum lycopersicum L.; Lycopersicon lycopersicum; Lycopersicum esculentum; Solanum lycopersicon
Rank
species
Lineage
Show more ... heophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum; Lycopersicon
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
tomato
Synonyms
Lycopersicon esculentum var. esculentum; Solanum esculentum; Solanum lycopersicum var. humboldtii; tomato; Lycopersicon esculentum Mill.; Solanum esculentum Dunal; Solanum lycopersicum L.; Lycopersicon lycopersicum; Lycopersicum esculentum; Solanum lycopersicon
Rank
species
Lineage
Show more ... heophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum; Lycopersicon
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
UniProtKB
Arabidopsis thaliana
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
-
Experimental Evidence
Authors
Quadrana L; Almeida J; Asís R; Duffy T; Dominguez PG; Bermúdez L; Conti G; Corrêa da Silva JV; et al. ... show more
Abstract
Vitamin E (VTE) content is a low heritability nutritional trait for which the genetic determinants are poorly understood. Here, we focus on a previously detected major tomato VTE quantitative trait loci (QTL; mQTL(9-2-6)) and identify the causal gene as one encoding a 2-methyl-6-phytylquinol methyltransferase (namely VTE3(1)) that catalyses one of the final steps in the biosynthesis of γ- and α-tocopherols, which are the main forms of VTE. By reverse genetic approaches, expression analyses, siRNA profiling and DNA methylation assays, we demonstrate that mQTL(9-2-6) is an expression QTL associated with differential methylation of a SINE retrotransposon located in the promoter region of VTE3(1). Promoter DNA methylation can be spontaneously reverted leading to different epialleles affecting VTE3(1) expression and VTE content in fruits. These findings indicate therefore that naturally occurring epialleles are responsible for regulation of a nutritionally important metabolic QTL and provide direct evidence of a role for epigenetics in the determination of agronomic traits.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
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