GEPHE SUMMARY
Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001702
Main curator
Courtier
PHENOTYPIC CHANGE
Trait #1
Trait Category
Trait
Trait State in Taxon A
no response to hexanoic acid
Trait State in Taxon B
response to hexanoic acid
Trait #2
Trait Category
Trait State in Taxon A
oviposition preference for butyric acid (versus hexanoic acid)
Trait State in Taxon B
oviposition preference for hexanoic acid (versus butyric acid)
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
fruit fly
Synonyms
Sophophora melanogaster; fruit fly; Drosophila melanogaster Meigen, 1830; Sophophora melanogaster (Meigen, 1830); Drosophila melangaster
Rank
species
Lineage
Show more ...
Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
-
Synonyms
Drosophila sechellia Tsacas and Bachli, 1981
Rank
species
Lineage
Show more ...
Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae; Drosophilinae; Drosophilini; Drosophila; Sophophora; melanogaster group; melanogaster subgroup
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
Ir75b
Synonyms
Ir75abc; IR75abc; CG14586; CG14586-B; CG42643; DmelIR75b; Dmel\CG42643; IR75b; Dmel_CG42643
String
Sequence Similarities
-
GO - Molecular Function
GO:0015276 : ligand-gated ion channel activity
... show more
GO - Biological Process
GO - Cellular Component
UniProtKB
Drosophila melanogaster
Drosophila melanogaster
GenebankID or UniProtKB
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
T523S in the LBD domain - caused by C1568G
Experimental Evidence
| Taxon A | Taxon B | Position | |
|---|---|---|---|
| Codon | - | - | - |
| Amino-acid | - | - | - |
Authors
Prieto-Godino LL; Rytz R; Cruchet S; Bargeton B; Abuin L; Silbering AF; Ruta V; Dal Peraro M; et al.
... show more
Abstract
Animals adapt their behaviors to specific ecological niches, but the genetic and cellular basis of nervous system evolution is poorly understood. We have compared the olfactory circuits of the specialist Drosophila sechellia-which feeds exclusively on Morinda citrifolia fruit-with its generalist cousins D. melanogaster and D. simulans. We show that D. sechellia exhibits derived odor-evoked attraction and physiological sensitivity to the abundant Morinda volatile hexanoic acid and characterize how the responsible sensory receptor (the variant ionotropic glutamate receptor IR75b) and attraction-mediating circuit have evolved. A single amino acid change in IR75b is sufficient to recode it as a hexanoic acid detector. Expanded representation of this sensory pathway in the brain relies on additional changes in the IR75b promoter and trans-acting loci. By contrast, higher-order circuit adaptations are not apparent, suggesting conserved central processing. Our work links olfactory ecology to structural and regulatory genetic changes influencing nervous system anatomy and function.
Copyright © 2017 Elsevier Inc. All rights reserved.
Copyright © 2017 Elsevier Inc. All rights reserved.
RELATED GEPHE
Related Genes
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
The difference in hexanoic acid olfaction is associated with the amino acid change T523S. The difference in oviposition site is associated with Ir75b full coding region and the effect of T523S on oviposition preference has not been tested.
YOUR FEEDBACK is welcome!