GEPHE SUMMARY Print
Entry Status
Published
GepheID
GP00001764
Main curator
Santos
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
nonstriped
Trait State in Taxon B
striped
Ancestral State
Unknown
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Haplochromis nyererei; Pundamilia nyererei (Witte-Maas & Witte, 1985); Pundamilia neyereri
Rank
species
Lineage
Show more ... Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini; Pundamilia
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B #1
Common Name
-
Synonyms
Ctenochromis sauvagei; Haplochromis 'rock kribensis'; Paralabidochromis rockkribensis; Ptyochromis sauvagei; Ctenochromis sauvagei Pfeffer, 1896; Ptyochromis sauvagei (Pfeffer, 1896); ZMB 22.222; ZMB:22.222
Rank
species
Lineage
Show more ... rypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini; Haplochromis
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
Taxon B #2
Common Name
-
Synonyms
Paralabidochromis chilotes; Paratilapia chilotes; Haplochromis chilotes (Boulenger, 1911); Paratilapia chilotes Boulenger, 1911
Rank
species
Lineage
Show more ... rypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini; Haplochromis
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
asip2b
Synonyms
A2; asip; agrp2; asip2; AgRP2
String
-
Sequence Similarities
-
UniProtKB
Danio rerio
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Molecular Details of the Mutation
Causal mutation(s) are in a 1.1-kb interval within the first agrp2 intron
Experimental Evidence
Authors
Kratochwil CF; Liang Y; Gerwin J; Woltering JM; Urban S; Henning F; Machado-Schiaffino G; Hulsey CD; et al. ... show more
Abstract
The color patterns of African cichlid fishes provide notable examples of phenotypic convergence. Across the more than 1200 East African rift lake species, melanic horizontal stripes have evolved numerous times. We discovered that regulatory changes of the gene agouti-related peptide 2 (agrp2) act as molecular switches controlling this evolutionarily labile phenotype. Reduced agrp2 expression is convergently associated with the presence of stripe patterns across species flocks. However, cis-regulatory mutations are not predictive of stripes across radiations, suggesting independent regulatory mechanisms. Genetic mapping confirms the link between the agrp2 locus and stripe patterns. The crucial role of agrp2 is further supported by a CRISPR-Cas9 knockout that reconstitutes stripes in a nonstriped cichlid. Thus, we unveil how a single gene affects the convergent evolution of a complex color pattern.

Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
@Parallelism
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