GEPHE SUMMARY Print
Gephebase Gene
beta-tubulin
Entry Status
Published
GepheID
GP00001786
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Physiology
Trait
Xenobiotic resistance (benzimidazole)
Trait State in Taxon A
sensitive
Trait State in Taxon B
resistant
Ancestral State
Taxon A
Taxonomic Status
Intraspecific
Taxon A
Latin Name
Trichostrongylus colubriformis
Common Name
-
Synonyms
-
Rank
species
Lineage
Show more ... isms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Trichostrongylus
Parent
Trichostrongylus () - (Rank: genus)
NCBI Taxonomy ID
6319
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Trichostrongylus colubriformis
Common Name
-
Synonyms
-
Rank
species
Lineage
Show more ... isms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Strongyloidea; Trichostrongylidae; Trichostrongylus
Parent
Trichostrongylus () - (Rank: genus)
NCBI Taxonomy ID
6319
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
TUB2
Synonyms
ARM10; SHE8; YFL037W
String
4932.YFL037W
Sequence Similarities
Belongs to the tubulin family.
GO - Molecular Function
GO:0005525 : GTP binding ... show more
GO - Biological Process
GO:0007010 : cytoskeleton organization ... show more
GO - Cellular Component
GO:0005737 : cytoplasm ... show more
UniProtKB
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P02557
GenebankID or UniProtKB
A2TF56
Presumptive Null
No
Molecular Type
Coding
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Phe200Tyr
Experimental Evidence
Candidate Gene
Taxon A Taxon B Position
Codon - - -
Amino-acid Phe Tyr 200
Main Reference
Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in beta-tubulin isotype 1. (1994)
Authors
Kwa MS; Veenstra JG; Roos MH
Abstract
-
Additional References
Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles. (2018)
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
Effect of the amino acid change tested in C. elegans
YOUR FEEDBACK is welcome!