GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00001807
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Fundulus heteroclitus - sensitive - lives in non-polluted sites
Trait State in Taxon B
Fundulus heteroclitus - tolerant - adapted to polluted sites
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
mummichog
Synonyms
mummichog; Atlantic killifish; killifish; Fundulus heteroclitus (Linnaeus, 1766)
Rank
species
Lineage
Show more ... leosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Fundulidae; Fundulus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
mummichog
Synonyms
mummichog; Atlantic killifish; killifish; Fundulus heteroclitus (Linnaeus, 1766)
Rank
species
Lineage
Show more ... leosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontoidei; Fundulidae; Fundulus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
population T1 and T3
GENOTYPIC CHANGE
Generic Gene Name
Ahr
Synonyms
Ah; In; Ahh; Ahre; bHLHe76
Sequence Similarities
-
GO - Biological Process
GO:0045944 : positive regulation of transcription by RNA polymerase II ... show more
UniProtKB
Mus musculus
GenebankID or UniProtKB
Presumptive Null
Yes
Molecular Type
Aberration Type
Deletion Size
10-100 kb
Molecular Details of the Mutation
45 kb deletion that removes parts of the two genes AHR1a and AHR2a (from exon 5 of AHR2a to exon 4 of AHR1a)
Experimental Evidence
Authors
Reid NM; Proestou DA; Clark BW; Warren WC; Colbourne JK; Shaw JR; Karchner SI; Hahn ME; et al. ... show more
Abstract
Atlantic killifish populations have rapidly adapted to normally lethal levels of pollution in four urban estuaries. Through analysis of 384 whole killifish genome sequences and comparative transcriptomics in four pairs of sensitive and tolerant populations, we identify the aryl hydrocarbon receptor-based signaling pathway as a shared target of selection. This suggests evolutionary constraint on adaptive solutions to complex toxicant mixtures at each site. However, distinct molecular variants apparently contribute to adaptive pathway modification among tolerant populations. Selection also targets other toxicity-mediating genes and genes of connected signaling pathways; this indicates complex tolerance phenotypes and potentially compensatory adaptations. Molecular changes are consistent with selection on standing genetic variation. In killifish, high nucleotide diversity has likely been a crucial substrate for selective sweeps to propel rapid adaptation.

Copyright © 2016, American Association for the Advancement of Science.
RELATED GEPHE
Related Genes
Related Haplotypes
2
COMMENTS
Knockdown of AHR2a is protective of toxicity - @Parallelism @Fitness
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