GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00001809
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Atlantic tomcod - sensitive
Trait State in Taxon B
Atlantic tomcod - tolerant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
Atlantic tomcod
Synonyms
Atlantic tomcod
Rank
species
Lineage
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Osteoglossocephalai; Clupeocephala; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Paracanthomorphacea; Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Microgadus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
Atlantic tomcod
Synonyms
Atlantic tomcod
Rank
species
Lineage
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Osteoglossocephalai; Clupeocephala; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Paracanthomorphacea; Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Microgadus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
Yes
Taxon B Description
population in Hudson river
GENOTYPIC CHANGE
Generic Gene Name
Ahr
Synonyms
Ah; In; Ahh; Ahre; bHLHe76
String
Sequence Similarities
-
GO - Molecular Function
GO:0042803 : protein homodimerization activity
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GO - Biological Process
GO - Cellular Component
GO:0005737 : cytoplasm
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Presumptive Null
Molecular Type
Aberration Type
Deletion Size
1-9 bp
Molecular Details of the Mutation
6-bp deletion - (nts 1314 to 1319 in exon 10; TTCCTC) that resulted in a two-amino acid (Phe-Leu) deletion located 43 amino acids downstream of the amino terminal of the AHR2 ligand binding domain
Experimental Evidence
Main Reference
Authors
Wirgin I; Roy NK; Loftus M; Chambers RC; Franks DG; Hahn ME
Abstract
The mechanistic basis of resistance of vertebrate populations to contaminants, including Atlantic tomcod from the Hudson River (HR) to polychlorinated biphenyls (PCBs), is unknown. HR tomcod exhibited variants in the aryl hydrocarbon receptor 2 (AHR2) that were nearly absent elsewhere. In ligand-binding assays, AHR2-1 protein (common in the HR) was impaired as compared to widespread AHR2-2 in binding TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and in driving expression in reporter gene assays in AHR-deficient cells treated with TCDD or PCB126. We identified a six-base deletion in AHR2 as the basis of resistance and suggest that the HR population has undergone rapid evolution, probably due to contaminant exposure. This mechanistic basis of resistance in a vertebrate population provides evidence of evolutionary change due to selective pressure at a single locus.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
EXTERNAL LINKS
COMMENTS
Knockdown of AHR2 is protective of toxicity in killifish
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