GEPHE SUMMARY
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Gephebase Gene
Entry Status
Published
GepheID
GP00001815
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
sensitive
Trait State in Taxon B
resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
-
Synonyms
Ostertagia circumcincta; Teladoragia circumcincta
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Strongylida; Trichostrongyloidea; Haemonchidae; Teladorsagia
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
-
Synonyms
Ostertagia circumcincta; Teladoragia circumcincta
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Strongylida; Trichostrongyloidea; Haemonchidae; Teladorsagia
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
TUB2
Synonyms
ARM10; SHE8; YFL037W
String
Sequence Similarities
Belongs to the tubulin family.
GO - Molecular Function
GO:0005525 : GTP binding
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GO - Biological Process
GO:0007010 : cytoskeleton organization
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GO - Cellular Component
GO:0005737 : cytoplasm
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UniProtKB
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Presumptive Null
Molecular Type
Aberration Type
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Phe200Tyr
Experimental Evidence
| Taxon A | Taxon B | Position | |
|---|---|---|---|
| Codon | - | - | - |
| Amino-acid | Phe | Tyr | 200 |
Authors
Elard L; Humbert JF
Abstract
In this work we demonstrated that the acquisition of benzimidazole (BZ) resistance in the small-ruminant parasite Teladorsagia circumcincta is linked to the selection of individuals that are characterized by a tyrosine (Tyr) at amino acid 200 of their isotype 1 beta-tubulin gene. This mutation appears to be recessive, since only homozygous mutant (Tyr/Tyr) individuals survived after BZ treatment of two resistant populations in which the three genotypes (rr, rs, ss) were initially present. In comparison with natural BZ-susceptible populations, a decrease in the restriction polymorphism (RFLP) of the isotype 1 beta-tubulin gene was observed in natural resistant populations. It seems that this decrease in beta-tubulin polymorphism results from the selection of homozygous mutant individuals.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
EXTERNAL LINKS
COMMENTS
Effect of the amino acid change tested in C. elegans
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