GEPHE SUMMARY Print
Gephebase Gene
beta-tubulin
Entry Status
Published
GepheID
GP00001816
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Physiology
Trait
Xenobiotic resistance (benzimidazole)
Trait State in Taxon A
sensitive
Trait State in Taxon B
resistant
Ancestral State
Taxon A
Taxonomic Status
Intraspecific
Taxon A
Latin Name
Haemonchus contortus
Common Name
barber pole worm
Synonyms
barber pole worm; red stomach worm; Haemonchus contortus (Rudolphi, 1803)
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchus
Parent
Haemonchus () - (Rank: genus)
NCBI Taxonomy ID
6289
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Haemonchus contortus
Common Name
barber pole worm
Synonyms
barber pole worm; red stomach worm; Haemonchus contortus (Rudolphi, 1803)
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchus
Parent
Haemonchus () - (Rank: genus)
NCBI Taxonomy ID
6289
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
TUB2
Synonyms
ARM10; SHE8; YFL037W
String
4932.YFL037W
Sequence Similarities
Belongs to the tubulin family.
GO - Molecular Function
GO:0005525 : GTP binding ... show more
GO - Biological Process
GO:0007010 : cytoskeleton organization ... show more
GO - Cellular Component
GO:0005737 : cytoplasm ... show more
UniProtKB
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P02557
GenebankID or UniProtKB
A2TF56
Presumptive Null
No
Molecular Type
Coding
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
Phe167Tyr - In vitro assays have demonstrated that a Tyr residue in position 167 of b-tubulin impeded BZ binding with recombinant H. contortus b-tubulin (produced in a prokaryote system)
Experimental Evidence
Candidate Gene
Taxon A Taxon B Position
Codon - - -
Amino-acid Phe Tyr 167
Main Reference
Polymerisation and benzimidazole binding assays with recombinant α-and β-tubulins from Haemonchus contortus . (2000 )
Authors
Prichard R; Oxberry M; Bounhas Y; Sharma S; Lubega G; Geary T
Abstract
-
Additional References
Mutation in position 167 of isotype 1 beta-tubulin gene of Trichostrongylid nematodes: role in benzimidazole resistance?. (2002)
Site-directed mutagenesis of Saccharomyces cerevisiae beta-tubulin: interaction between residue 167 and benzimidazole compounds. (1996)
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
2
EXTERNAL LINKS
COMMENTS
This mutation Phe167Tyr is different from Phe200Tyr which is found in other resistant strains Main paper not curated - information curated from Sylvestre and Cabaret paper.
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