GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001859
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Cimex lectularius
Trait State in Taxon B
Cimex lectularius - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
bed bug
Synonyms
bed bug; Cimex lectularius Linnaeus, 1758; Cimex lectularis
Rank
species
Lineage
Show more ... acea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Hemiptera; Prosorrhyncha; Heteroptera; Euheteroptera; Neoheteroptera; Panheteroptera; Cimicomorpha; Cimicoidea; Cimicidae; Cimex
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
bed bug
Synonyms
bed bug; Cimex lectularius Linnaeus, 1758; Cimex lectularis
Rank
species
Lineage
Show more ... acea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Hemiptera; Prosorrhyncha; Heteroptera; Euheteroptera; Neoheteroptera; Panheteroptera; Cimicomorpha; Cimicoidea; Cimicidae; Cimex
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Mutation #1
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
L925I
Experimental Evidence
Taxon A Taxon B Position
Codon CTT ATT -
Amino-acid Leu Ile 925
Authors
Durand R; Cannet A; Berdjane Z; Bruel C; Haouchine D; Delaunay P; Izri A
Abstract
Bed bugs are hematophagous insects responsible for a re-emerging and challenging indoor pest in many countries. Bed bugs infestations may have health consequences including nuisance biting, cutaneous and systemic reactions. This resurgence can probably be attributed to factors such as increased international travel and development of resistance against insecticides. Resistance against pyrethroids has been reported several times from the USA and rarely in Europe. In France, very few data on bed bugs are available. The present study aimed to assess the infestation by bed bugs of a complex of two high-rise apartment buildings in the suburb of Paris and to evaluate their susceptibility to pyrethroid insecticides. We inspected for bed bugs 192 out of 198 apartments units (97%) and interviewed their residents. 76 (39.6%) apartments were infested. Among the 97 residents living in infested apartments, 53 (54.6%) reported bed bug bites. A total of 564 bed bugs were collected in the infested units. Bioassays showed that 54 out of 143 bed bugs were resistant to pyrethroids (37.8%; 95% confidence interval: 29.9-45.7%). DNA sequencing showed that all bed bugs tested (n=124) had homozygous L925I kdr-like gene mutation. The level of pyrethroid resistance found indicates that this phenomenon was already established in the site and prompts the need to reevaluate the wide use of pyrethroids to control bed bugs.
Mutation #2
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
V419M - a Val to Met mutation at the corresponding position of the bed bug V419 has been identified in the tobacco budworm Heliothis virescens (Park et al. 1997) and functionally validated as a kdr-type mutation (Lee and Soderlund 2001)
Experimental Evidence
Taxon A Taxon B Position
Codon GTC CTC -
Amino-acid Val Met 419
Authors
Durand R; Cannet A; Berdjane Z; Bruel C; Haouchine D; Delaunay P; Izri A
Abstract
Bed bugs are hematophagous insects responsible for a re-emerging and challenging indoor pest in many countries. Bed bugs infestations may have health consequences including nuisance biting, cutaneous and systemic reactions. This resurgence can probably be attributed to factors such as increased international travel and development of resistance against insecticides. Resistance against pyrethroids has been reported several times from the USA and rarely in Europe. In France, very few data on bed bugs are available. The present study aimed to assess the infestation by bed bugs of a complex of two high-rise apartment buildings in the suburb of Paris and to evaluate their susceptibility to pyrethroid insecticides. We inspected for bed bugs 192 out of 198 apartments units (97%) and interviewed their residents. 76 (39.6%) apartments were infested. Among the 97 residents living in infested apartments, 53 (54.6%) reported bed bug bites. A total of 564 bed bugs were collected in the infested units. Bioassays showed that 54 out of 143 bed bugs were resistant to pyrethroids (37.8%; 95% confidence interval: 29.9-45.7%). DNA sequencing showed that all bed bugs tested (n=124) had homozygous L925I kdr-like gene mutation. The level of pyrethroid resistance found indicates that this phenomenon was already established in the site and prompts the need to reevaluate the wide use of pyrethroids to control bed bugs.
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
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COMMENTS
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