GEPHE SUMMARY Print
Gephebase Gene
Entry Status
Published
GepheID
GP00001865
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Myzus persicae
Trait State in Taxon B
Myzus persicae - resistant
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Latin Name
Common Name
green peach aphid
Synonyms
Myzus (Nectarosiphon) persicae; green peach aphid; peach-potato aphid; Myzus persicae (Sulzer, 1776); Myzus persiceae
Rank
species
Lineage
Show more ... Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha; Aphidoidea; Aphididae; Aphidinae; Macrosiphini; Myzus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Latin Name
Common Name
green peach aphid
Synonyms
Myzus (Nectarosiphon) persicae; green peach aphid; peach-potato aphid; Myzus persicae (Sulzer, 1776); Myzus persiceae
Rank
species
Lineage
Show more ... Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota; Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha; Aphidoidea; Aphididae; Aphidinae; Macrosiphini; Myzus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Presumptive Null
No
Molecular Type
Aberration Type
SNP
SNP Coding Change
Nonsynonymous
Molecular Details of the Mutation
M918L
Experimental Evidence
Taxon A Taxon B Position
Codon ATG TTG -
Amino-acid Met Leu 918
Authors
Panini M; Anaclerio M; Puggioni V; Stagnati L; Nauen R; Mazzoni E
Abstract
Pyrethroids have been widely employed in order to control several agricultural pests, including Myzus persicae. Target-site resistance is the main mechanism that confers insensitivity to this class of compounds, and the most common amino acid substitutions are kdr (L1014F) and s-kdr (M918T), but recently another mutation in the s-kdr locus (M918L) has been described in French and Korean populations of M. persicae.

Molecular analysis of several Italian populations of M. persicae by pyrosequencing revealed the presence of the new s-kdr mutation (M918L) in different forms. It was found in two different nucleotide polymorphisms (a/t or a/c substitution), in heterozygous or homozygous status, and also in combination with the classic kdr and s-kdr. Bioassays on populations carrying the M918L mutation show that it strongly affects pyrethroid efficacy, particularly of type II pyrethroids such as lambda-cyhalothrin, while it has no effect against DDT.

This work provides more information about the new s-kdr M918L mutation in M. persicae, describing a more complicated situation arising from the possible combination with the classic L1014F and M918T. Our data open new questions concerning the origin of these new genotypes with different combinations of target-site mutations, and also their possible influence on control strategies.

© 2014 Society of Chemical Industry.
EXTERNAL LINKS
COMMENTS
The same amino acid change is also found in M. persicae populations via another nucleotide change
YOUR FEEDBACK is welcome!