GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00001881
Main curator
Courtier
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Candida albicans and Saccharomyces cerevisiae - prototroph for nicotinic acid -
can synthesize nicotinic acid mononucleotide (NaMN) from tryptophan via the kynurenine pathway
Trait State in Taxon B
Candida glabrata - auxotroph for nicotinic acid
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Candida stellatoidea; Candida stellatoidea type I; ATCC 11006; ATCC 18804; ATCC 20308; ATCC:11006; ATCC:18804; ATCC:20308; BCC 5390; BCC:5390; BCRC 20512; BCRC:20512; CBS 562; CBS:562; CCRC 20512; CCRC:20512; CECT 1002; CECT:1002; IFO 1385; IFO:1385; JCM 1537; JCM 1542; JCM:1537; JCM:1542; KCTC 7270; KCTC:7270; MUCL 29800; MUCL:29800; NBIMCC 72; NBIMCC:72; NBRC 1385; NBRC:1385; NCAIM Y.00971; NCYC 597; NCYC:597; NRRL Y-12983; NRRL:Y:12983; PYCC 3436; PYCC:3436; UAMH 8765; UAMH:8765; Candida albican
Rank
species
Lineage
cellular organisms; Eukaryota; Opisthokonta; Fungi; Dikarya; Ascomycota; saccharomyceta; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
-
Synonyms
Candida glabrata; Cryptococcus glabratus; Torulopsis glabrata; Cryptococcus glabratus H.W. Anderson, 1917; ATCC 2001; ATCC:2001; BCRC:20586; CBS 138; CBS:138; CCRC 20586; CCRC:20586; DBVPG 3828; DBVPG:3828; IFO 0622; IFO:0622; JCM 3761; JCM:3761; KCTC 1714; KCTC:1714; NCPF 3309; NCPF:3309; NRRL Y-1417; NRRL Y-65; NRRL:Y:1417; NRRL:Y:65; Candidia glabrata
Rank
species
Lineage
Show more ... lular organisms; Eukaryota; Opisthokonta; Fungi; Dikarya; Ascomycota; saccharomyceta; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces; Nakaseomyces/Candida clade
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Presumptive Null
Yes
Molecular Type
Aberration Type
Deletion Size
unknown
Molecular Details of the Mutation
Size of the deletion not mentioned in the paper
Experimental Evidence
Authors
Domergue R; Castaño I; De Las Peñas A; Zupancic M; Lockatell V; Hebel JR; Johnson D; Cormack BP
Abstract
The adherence of Candida glabrata to host cells is mediated, at least in part, by the EPA genes, a family of adhesins encoded at subtelomeric loci, where they are subject to transcriptional silencing. We show that normally silent EPA genes are expressed during murine urinary tract infection (UTI) and that the inducing signal is the limitation of nicotinic acid (NA), a precursor of nicotinamide adenine dinucleotide (NAD+). C. glabrata is an NA auxotroph, and NA-induced EPA expression is likely the result of a reduction in NAD+ availability for the NAD+-dependent histone deacetylase Sir2p. The adaptation of C. glabrata to the host, therefore, involves a loss of metabolic capacity and exploitation of the resulting auxotrophy to signal a particular host environment.
Additional References
RELATED GEPHE
Related Haplotypes
No matches found.
COMMENTS
Loss of four de novo biosynthesis of nicotinic acid (BNA) genes (all except BNA3 were lost) is associated with increased pathogenicity: the nicotinid acid present in the urinary tract activates expression of epithelial adhesion (EPA) genes in C. glabrata; thus activating adherence to host cells within the renal system. @& UniprotKB not fetched
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