GEPHE SUMMARY
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									Gephebase Gene
					
		
	
									Entry Status
					
		
													Published
					
	
									GepheID
					
		
													GP00001947
					
	
									Main curator
					
		
													Courtier
					
	
            		PHENOTYPIC CHANGE
            	            
	                
	
									Trait Category
					
		
	
									Trait State in Taxon A
					
		
													able to synthesise cholesterol de novo
					
	
									Trait State in Taxon B
					
		
													unable to synthesise cholesterol de novo
					
	
									Ancestral State
					
		
													Taxon A
					
	
									Taxonomic Status
					
		
	Taxon A
					
									Latin Name
					
		
	
									Common Name
					
		
																			human
					
	
									Synonyms
					
		
																			human; man; Homo sapiens Linnaeus, 1758; Home sapiens; Homo sampiens; Homo sapeins; Homo sapian; Homo sapians; Homo sapien; Homo sapience; Homo sapiense; Homo sapients; Homo sapines; Homo spaiens; Homo spiens; Humo sapiens
					
	
									Rank
					
		
																			species
					
	
		Lineage
	
	
															
				Show more ... 
						opterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo
			
			
							Parent
					
		
	
							NCBI Taxonomy ID
					
		
	
									is Taxon A an Infraspecies?
					
		
																													No
					
	Taxon B
					
									Latin Name
					
		
	
									Common Name
					
		
																				-
					
	
									Synonyms
					
		
																			roundworm; Rhabditis elegans; Caenorhabditis elegans (Maupas, 1900); Rhabditis elegans Maupas, 1900
					
	
									Rank
					
		
																			species
					
	
		Lineage
	
	
															
				Show more ... 
						s; Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
			
			
							NCBI Taxonomy ID
					
		
	
									is Taxon B an Infraspecies?
					
		
																													No
					
	
            GENOTYPIC CHANGE
            	            
	                
	
									Generic Gene Name
					
		
																			FDFT1
					
	
									Synonyms
					
		
																			SS; SQS; DGPT; ERG9; SQSD
					
	
									String
					
		
	
									Sequence Similarities
					
		
																			Belongs to the phytoene/squalene synthase family.
					
	
							GO - Molecular Function
						
						
																														GO:0046872 : metal ion binding
							
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							GO - Biological Process
						
						
																														GO:0006695 : cholesterol biosynthetic process
							
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							GO - Cellular Component
						
						
																														GO:0016021 : integral component of membrane
							
									 ... show more
										
																					
					
									UniProtKB
																							
Homo sapiens
						
					Homo sapiens
									Presumptive Null
					
		
	
									Molecular Type
					
		
	
									Aberration Type
					
		
	
									Deletion Size
					
		
													unknown
					
	
									Molecular Details of the Mutation
					
		
													gene absent in the genome
					
	
									Experimental Evidence
					
		
	
				Main Reference
	
	
				Authors
	
	
									Kurzchalia TV; Ward S
										
							Abstract
					
		
																			Cholesterol is a structural component of animal membranes that influences fluidity, permeability and formation of lipid microdomains. It is also a precursor to signalling molecules, including mammalian steroid hormones and insect ecdysones. The nematode Caenorhabditis elegans requires too little cholesterol for it to have a major role in membrane structure. Instead, its most probable signalling functions are to control molting and induce a specialized non-feeding larval stage, although no cholesterol-derived signalling molecule has yet been identified for these or any other functions.
					
	
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