GEPHE SUMMARY
Gephebase Gene
Entry Status
Published
GepheID
GP00001959
Main curator
Santos
PHENOTYPIC CHANGE
Trait Category
Trait State in Taxon A
Low physiological ability to survive in freshwater DHA free diets
Trait State in Taxon B
High physiological ability to survive in freshwater DHA free diets
Ancestral State
Taxon A
Taxonomic Status
Taxon A
Common Name
-
Synonyms
Gasterosteus nipponicus Higuichi, Sakai & Gotu, 2014; HUMZ 97486; HUMZ:97486
Rank
species
Lineage
Show more ... a; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Gasterosteus
NCBI Taxonomy ID
is Taxon A an Infraspecies?
No
Taxon B
Common Name
three-spined stickleback
Synonyms
three-spined stickleback; three spined stickleback; Gasterosteus aculeatus Linnaeus, 1758
Rank
species
Lineage
Show more ... a; Euteleosteomorpha; Neoteleostei; Eurypterygia; Ctenosquamata; Acanthomorphata; Euacanthomorphacea; Percomorphaceae; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Gasterosteus
NCBI Taxonomy ID
is Taxon B an Infraspecies?
No
GENOTYPIC CHANGE
Generic Gene Name
fads2
Synonyms
Fadsd6; DRD5/D6; wu:fb64c04; wu:fb69e08; zgc:112502; fadsd6
Sequence Similarities
Belongs to the fatty acid desaturase type 1 family.
UniProtKB
Danio rerio
GenebankID or UniProtKB
Presumptive Null
No
Molecular Type
Aberration Type
Insertion Size
1-10 kb
Molecular Details of the Mutation
Fads2 locus is duplicated in G. aculeatus increasing DHA intake and the propensity to invade of freshwater environments. The ancestral copy is on linkage group 19 and the derived copy is on linkage group 12.
Experimental Evidence
Authors
Ishikawa A; Kabeya N; Ikeya K; Kakioka R; Cech JN; Osada N; Leal MC; Inoue J; et al. ... show more
Abstract
Colonization of new ecological niches has triggered large adaptive radiations. Although some lineages have made use of such opportunities, not all do so. The factors causing this variation among lineages are largely unknown. Here, we show that deficiency in docosahexaenoic acid (DHA), an essential ω-3 fatty acid, can constrain freshwater colonization by marine fishes. Our genomic analyses revealed multiple independent duplications of the fatty acid desaturase gene Fads2 in stickleback lineages that subsequently colonized and radiated in freshwater habitats, but not in close relatives that failed to colonize. Transgenic manipulation of Fads2 in marine stickleback increased their ability to synthesize DHA and survive on DHA-deficient diets. Multiple freshwater ray-finned fishes also show a convergent increase in Fads2 copies, indicating its key role in freshwater colonization.

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Additional References
RELATED GEPHE
Related Genes
No matches found.
Related Haplotypes
No matches found.
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